Regular articleBreakdown of the Inner and Outer Blood Retinal Barrier in Streptozotocin-Induced Diabetes
References (14)
Fluorescein distribution in retinas of normal and diabetic rats
Exp. Eye Res.
(1985)- et al.
Freeze-fracture and lanthanium studies of the retinal microvasculature in diabetic rats
Invest. Ophthalmol. Vis. Sci.
(1992) - et al.
Lanthanum and freeze-fracture studies of retinal pigment epithelial cell tight junctions in the streptozotocin diabetic rat
Curr. Eye Res.
(1985) - et al.
Studies on the permeability of the blood-retinal barrier
Br. J. Ophthalmol.
(1966) - et al.
The active transport of fluorescein by the retinal vessels and the retina
J. Physiol.
(1967) - et al.
Early breakdown of the blood-retinal barrier in diabetes
Br. J. Ophthalmol.
(1975) - et al.
Histamine H1 receptors mediate increased blood-retinal barrier permeability in experimental diabetes
Arch. Ophthalmol.
(1989)
Cited by (118)
Effect of intravitreal ranibizumab on serous retinal detachment in diabetic macular edema
2022, Journal of Diabetes and its ComplicationsCitation Excerpt :The presence of SRD in DME affects the outcomes of treatment and prognosis. The pathophysiology of SRD is complex and multifactorial.14,15 SRD occurs as a result of the breakdown of the outer blood-retinal barriers and the accumulation of fluid between the neurosensory retina and the retinal pigment epithelium.
Insulin-like growth factor-2 regulates basal retinal insulin receptor activity
2021, Journal of Biological ChemistryCitation Excerpt :The intraocular concentrations of ligands were also measured in vitreous gel extracted from the same animals. Coomassie staining showed a 3-fold higher total protein content (by protein assay) (Fig. 6Di and ii) from the diabetic rat eyes despite loading equal volumes of vitreous, likely because of blood–retinal barrier leakage (32). Nevertheless, diabetes reduced total rat vitreous IGF-2 content by 78%, and mature IGF-2 by 80% (Fig. 6Ei, ii and iii).
1.36 - Animal and Human Models of Retinal Diseases
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionUrsodeoxycholic acid ameliorates diabetic retinopathy via reducing retinal inflammation and reversing the breakdown of blood-retinal barrier
2018, European Journal of PharmacologyNeutralization of placental growth factor as a novel treatment option in diabetic retinopathy
2017, Experimental Eye ResearchCitation Excerpt :The diabetic STZ and Akimba models were mainly used to investigate the effect of PlGF inhibition on leakage. In preclinical settings, the role of the inner BRB has been well documented in the context of DR. recent studies have also proven the significance of the outer BRB in the pathophysiology of DR and DME in different diabetic rodent models, such as the STZ model (Do et al., 1998; Xu and Le, 2011; Xu et al., 2011). In the Akimba mice, it is also described that disturbances in the RPE cell layer can be discerned (Rakoczy et al., 2010; Wisniewska-Kruk et al., 2014) signifying the breakdown of the outer BRB.
Association of reduced Connexin 43 expression with retinal vascular lesions in human diabetic retinopathy
2016, Experimental Eye Research
- f1
Correspondence and reprint requests: IBILI—Dept of Ophthalmology, Azinhaga de Sta Comba, Celas, 3000 Coimbra, Portugal.