Regular articleOcular Surface Epithelia Express mRNA for Human Beta Defensin-2
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2020, Progress in Retinal and Eye ResearchCitation Excerpt :First evidence of AMP presence in the eye was reported two decades ago when we and others discovered that β-defensins are expressed by human corneal and conjunctival epithelial cells (Haynes et al., 1999, 1998; McNamara et al., 1999b). In our study, we additionally showed that these could be regulated by pathogen associated molecular patterns (McNamara et al., 1999b). Others have since shown that both IL-1β and TLR-receptor signaling also regulate the expression of AMPs at the ocular surface (McDermott et al., 2003; Redfern et al., 2011), and that AMPs are involved in resolving P. aeruginosa corneal infections after they are initiated by scratching (Wu et al., 2009).
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2013, American Journal of OphthalmologyCitation Excerpt :MyD88 regulation of defenses against bacterial adhesion to, and bacterial penetration of, the corneal epithelium would be consistent with junctional structure involvement in defense, since TLR signaling (dependent on MyD88 for most TLRs), along with other pattern recognition receptors, help regulate the function of tight junctions in other cell types.34 However, MyD88 involvement in defense against bacterial adhesion and traversal may also be attributable to its importance in regulating the expression of antimicrobial peptides, including human β-defensin-2 (hBD-2) and the cathelicidin LL-37, both of which are expressed by corneal epithelial cells after stimulation with TLR or IL-1R agonists.32,33,35,36 Indeed, we have already shown that hBD-2 is important in protecting the corneal epithelium against P aeruginosa colonization.37
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Address correspondence to: Nancy A. McNamara, Department of Anatomy, HSW-1330, University of California, San Francisco, CA 94143-0452, U.S.A.