Regular ArticleA New Dominant Retinal Degeneration (Rd4) Associated with a Chromosomal Inversion in the Mouse☆,☆☆
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Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells
2014, NeuronCitation Excerpt :Rd4 mice have a null mutation in rod transducin (Kitamura et al., 2006), whereas rd1 mice suffer from a null mutation in rod phosphodiesterase (Bowes et al., 1990). The rods and cones degenerate soon after birth in both of these mouse strains, leading to complete blindness by 6 weeks of age (Roderick et al., 1997; Sancho-Pelluz et al., 2008). As expected, untreated retinas from 3- to 6-month-old rd4 mice did not generate a light response, but DENAQ treatment did confer robust light responses (n = 6 retinas; p < 0.001, rank sum test) (Figure 4D), just like in the rd1 retina.
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Mapping data in this paper have been submitted to the Mouse Genome Database under Accession Nos. MGD-CREX-621, 622, 623, and 624.
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F. J. deSerresW. Sheridan, Eds.
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