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Evaluation of toxicity and efficacy of a combination of antineoplastic agents in the prevention of PVR

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Abstract

The retinal toxicity of a combination of antineoplastic drugs in free and liposome-encapsulated form was determined in the rabbit eye. Bleomycin sulfate and 5-fluorouridine were evaluated by clinical observation, electroretinogram, and histological study. Forty-five eyes were injected with combinations of various doses of bleomycin and 5-FUR in free and encapsulated form; 10 eyes served as controls. The nontoxic free dose was found to be 3.5μg bleomycin and 150μg 5-FUR. Liposome encapsulation increased the nontoxic dose to 4.7μg bleomycin and 200μg 5-FUR. Four groups of rabbits in which proliferative vitreoretinopathy had been induced were used for the efficacy study; the control group received an injection of PBS; the second group was injected with a combination of 3.5μg bleomycin and 150μg 5-FUR in free form; the third group was injected with the identical doses in liposome-encapsulated form; and the fourth group received encapsulated bleomycin (4.7μg) and 5-FUR (200μg). The dose used in Group 4 was significantly more effective (P<0.01) in preventing tractional retinal detachment and marginally more effective (P=0.054) in preventing neovascularization.

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Supported in part by U.S. Public Health Service grants EY07541 and EY02377 from the National Eye Institute, the National Institutes of Health Services, Bethesda, MD

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Salah-Eldin, M., Peyman, G.A., El-Aswad, M. et al. Evaluation of toxicity and efficacy of a combination of antineoplastic agents in the prevention of PVR. Int Ophthalmol 18, 53–60 (1994). https://doi.org/10.1007/BF00919240

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