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Intraocular extracellular cyclic nucleotide concentrations: the influence of vitreous surgery

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Abstract

Levels of cAMP (23.1 pmol/ml) and cGMP (22.6 pmol/ml) are nearly equal in normal rabbit vitreous, although aqueous CAMP levels (29.9 pmol/ml) are 10 times higher than aqueous cGMP levels (2.6 pmol/ml) (P<0.01). Intravitreal cAMP values decrease slightly 1 week after vitrectomy and lensectomy and return to normal whether the retina is attached, detached, or surgically removed. In contrast, intravitreal cGMP levels are profoundly depressed at 7 days (approximating normal aqueous levels) and are more than 50% lower than normal 30–42 days after surgery. The presence of these cyclic nucleotides in intraocular fluid and their responsiveness after surgery may signify a potential regulatory role in the physiologic responses of the eye to retinal detachment and its repair.

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This study was funded in part by NIH grants EY-02934, EY-05230, and EY-06520 and a grant from the William Beaumont Hospital Research Institute, Royal Oak, Michigan

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Dahna-Weiszhauz, J., Blumenkranz, M., Hartzer, M. et al. Intraocular extracellular cyclic nucleotide concentrations: the influence of vitreous surgery. Graefe's Arch Clin Exp Ophthalmol 231, 184–186 (1993). https://doi.org/10.1007/BF00920945

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  • DOI: https://doi.org/10.1007/BF00920945

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