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Soluble intercellular adhesion molecule 1 in spondylarthropathies

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Abstract

The aim of the study was to evaluate the soluble form of intercellular adhesion molecule 1 (sICAM-1), a ligand of LFA-1, in the serum of patients with spondylarthropathies (SpA) and to look for a correlation with several inflammatory parameters. sICAM-1 levels were measured by ELISA in 25 SpA patients, 20 healthy controls and 20 patients with rheumatoid arthritis (RA). Results showed that sICAM-1 levels were increased (but not significantly) in SpA patients compared with controls; high levels (>400 ng/ml) where found in 28% of SpA patients but in none of the RA or control groups. In SpA, correlations were found between sICAM-1 and erythrocyte sedimentation rate, C-reactive protein and interleukin 6, but not with tumour necrosis factor alapha or IgA. These correlations were absent in RA. In conclusion, these results suggest that sICAM-1 levels in SpA may reflect the acute phase of inflammation.

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Wendling, D., Racadot, E., Augé, B. et al. Soluble intercellular adhesion molecule 1 in spondylarthropathies. Clin Rheumatol 17, 202–204 (1998). https://doi.org/10.1007/BF01451047

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  • DOI: https://doi.org/10.1007/BF01451047

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