Abstract
Hemorheological factors were studied in 34 patients affected by retinal vein occlusion (RVO) and in 25 control subjects. Whole blood viscosity, plasma viscosity, fibrinogen and hematocrit were increased in RVO patients compared with controls. Whole-blood filterability was reduced in RVO patients compared with controls. However, when evaluating the type of capillaropathy at fluorescein angiography, blood viscosity and plasma viscosity were altered in both patients with and without evidence of capillary nonperfusion. Reduction of blood filterability showed statistical significance only in patients with capillary nonperfusion. This finding suggests that reduced whole-blood filterability might be a causal factor in the development of capillary nonperfusion in RVO patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brunner R, Heinen A, Konen W, Gaethgens P, Hossmann V (1983) Therapy of occlusive disease of retina by pentoxifillin, isovolemic hemodilution with ablbumine and hypervolemic hemodilution with dextran. A randomized double blind study. Clin Hemorrheol 3: 232
Chien S (1977) Rheology of sickle cells and erythrocyte content. Blood Cells 3: 283–303
Chien S (1981) Haemodynamic and rheology in the microcirculation. In Davis A, Marcel GA (eds) Recent developments in microcirculation research. Excerpta Medica, Amsterdam Oxford Princeton, p 54–69
Dormandy J (1983) Red cell deformability and filterability. Proceedings 2nd Workshop, London 23–24 September 1982, Martinus Nijoff, The Hague, p 101
Haeringen NJ van, Glasius E (1978) Erythrocyte aggregation in relation to thrombotic disorders of the retina. Interdiscipl Top Gerontol 13: 40–45
Hansen LL, Danisevkis P, Arntz HR, Hövener G, Wiederholt M (1983) Treatment of ischemic and non-ischemic central retinal vein occlusion by isovolemic hemodilution and panretinal coagulation. Clin Hemorrheol 3: 233
Kohner EM, Barnes AJ, Hill DW, Young S, Red HL, Dormandy JA (1979) Effect of viscosity on retinal blood flow. I. Effects of isovolumetric haemodilution. Concilium Ophthalmologicum 23rd, 1978, Kyoto, p 826
Koyama T, Kikuchi A (1982) Reduced red cell filterability due to red cell plasma protein interactions. Biorheology 19: 579–585
Little HL (1981) Alterations in blood elements in the pathogenesis of diabetic retinopathy. Ophthalmology 88: 647–654
Lowe GDO, Trope G, Ardle BM, Douglas JT, Foulds W, Forbes CD, Prentice CRM (1983) Abnormal blood viscosity and haemostasis in long-standing retinal vein occlusion. Br J Ophthalmol 67: 137
McGrath MA, Wechsler F, Hunyor ABL, Penny R (1978) Systemic factors contributing to retinal vein occlusion. Arch Int Med 138: 216
Melli M, Poggi M, Codeluppi L, Baraldi P, Torlai F, Peduzzi M (1983) La viscosità ematica e la deformabilità eritrocitaria nella retinopatia diabetica. Ric Clin Lab [Suppl] 13: 371–374
Oughton J, Chaine G, Barnes AJ, Arnold J, Hill DW, Houseman J, Fleming J, Kohner EM (1983) Effect of haemodilution on retinal blood flow. Clinical Hemorrheology 3: 234
Pandolfi M, Isacson S, Astedt B (1972) Coagulation and fibrinolytic studies in 23 patients with occlusion of retinal vessels. Acta Ophthalmol 50: 62–72
Peduzzi M, De Rosa V, Fonda S, Coccheri S (1981) Haemostatic studies in retinal vein occlusion. Fibrinolytic response to venostasis as a prognostic factor for spontaneous recanalization. Thromb Res 24: 105–118
Peduzzi M, Codeluppi L, Poggi M, Baraldi P (1983) Abnormal blood viscosity and erythrocyte deformability in retinal vein occlusion. Am J Ophthalmol 96: 399–400
Reid HL, Barnes AJ, Lock PJ, Dormandy A, Dormandy TL (1976) A simple method for measuring erythrocyte deformability. J Clin Pathol 29: 855–858
Ring CP, Pearson TC, Sanders MD, Wetherley-Mein G (1976) Viscosity and retinal vein thrombosis. Br J Ophthalmol 60: 397–410
Schmid-Schönbein H, Volger E (1975) Red cell aggregation and red cell deformability in diabetes. Diabetes [Suppl] 25: 897–902
Author information
Authors and Affiliations
Additional information
Presented at the 1984 meeting of the Club Jules Gonin in Lausanne, Switzerland
Rights and permissions
About this article
Cite this article
Peduzzi, M., Debbia, A., Guerrieri, F. et al. Abnormal blood rheology in retinal vein occlusion. Graefe's Arch Clin Exp Ophthalmol 224, 83–85 (1986). https://doi.org/10.1007/BF02144143
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02144143