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Münsteraner Altern- und Retinastudie (MARS)

Zusammenhang zwischen Risikofaktoren der Arteriosklerose und der altersabhängiger Makuladegeneration

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Zusammenfassung

Hintergrund

Der Zusammenhang zwischen Arteriosklerose und der altersabhängigen Makuladegeneration ist nur in wenigen Studien untersucht worden. Die Datenlage ist inkonsistent.

Methode

Es wurde eine Querschnittsuntersuchung bei 730 Patienten der Münsteraner Altern- und Retinastudie durchgeführt. Die Patienten wurden in 4 Gruppen eingeteilt: ohne, mit ein- oder beidseitiger früher Form, mit einseitig später, mit beidseitig späten Formen der AMD. Geprüft wurde, ob die Risikofaktoren für die Arteriosklerose in den Gruppen signifikant unterschiedlich ausfallen.

Ergebnisse

Bezüglich des Geschlechts unterschieden sich die Gruppen nicht signifikant, während das Alter mit Zunahme des Schweregrades der AMD anstieg. Allgemeine Risikofaktoren für die Arteriosklerose waren nicht signifikant unterschiedlich, während die Raucher mit Schweregrad der AMD in den Gruppen zunahmen. Bei den Fettstoffwechselparametern imponierte eine Abnahme des HDL-Wertes im Serum mit gleichzeitigem Anstieg des HDL/LDL-Quotienten sowie der nicht nüchtern bestimmten Triglyceridwerte bei schwerer AMD.

Schlussfolgerungen

Wir beobachten eine Zunahme der Dyslipidämieparameter und HDL-Abnahme mit der Schwere der AMD. Diese Befunde werden durch die Zunahme der Triglyceridwerte gestützt. Die Resultate müssen wegen des explorativen Charakters der Auswertungen zurückhaltend interpretiert werden.

Abstract

Background

The association between arteriosclerosis and age-related macular degeneration (AMD) has only been examined in a few studies and the data is still very inconsistent.

Methods

A cross sectional study was initiated with 730 patients from the Münster age and retina study (MARS) which examines patients in the age range 60 to 80 years old who were referred by ophthalmologists from the Muenster area. Patients with narrow angle glaucoma were excluded. All patients underwent a standardized ophthalmoscopic examination und were classified into four groups: group1 without AMD (n=190), group 2 with unilateral or bilateral early forms of AMD (n=340), group3 with unilateral late forms of AMD (n=139) and group 4 with bilateral late forms of AMD (n=50). By means of these groups it was tested if there was a significant difference between the different risk factors for arteriosclerosis.

Results

The mean age was 72 years and 58% were women and the sex distribution within the different groups did not differ significantly (all trend tests with p>0.1). General risk factors for arteriosclerosis such as diabetes, body-mass-index and hypertension did not differ significantly (all trend tests with p>0.1). The number of smokers increased significantly with the severity of AMD (p=0.02). Furthermore, various lipids were examined, adjusted for age and sex and showed significant decrease of HDL (p=0.087) and significant increases of the HDL/LDL quotient (p=0.0007) and the non-sober triglyceride values (p=0.0058) correlated with the severity of AMD.

Conclusions

There was a highly significant, direct association of indicators of dyslipidemia such as increasing HDL/LDL quotient and decreasing HDL with the severity of AMD. These results were underlined by increased triglyceride levels even if they were taken non-sober. The results must be interpreted with caution due to the explorative character of the evaluation.

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Diese Arbeit wurde gefördert im Rahmen des DFG-Schwerpunktprogramms „Altersabhängige Makuladegeneration“ (HE 2293/5-1).

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Correspondence to H. W. Hense.

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Dieser Beitrag wurde als Vortrag auf der 100. DOG 2002 gehalten.

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Wachter, A., Sun, Y., Dasch, B. et al. Münsteraner Altern- und Retinastudie (MARS). Ophthalmologe 101, 50–53 (2004). https://doi.org/10.1007/s00347-003-0868-1

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  • DOI: https://doi.org/10.1007/s00347-003-0868-1

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