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Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy

  • Retinal Disorders
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Abstract

Purpose

To investigate whether pan-retinal photocoagulation (PRP) affects vitreous levels of cytokines and macular thickening in patients with high-risk proliferative diabetic retinopathy (PDR).

Methods

Fourteen patients with bilateral high-risk PDR—which requires pars plana vitrectomy (PPV)—but without a history of retinal photocoagulation participated in this study. Before PPV, one eye received PRP, and the other eye did not. The concentrations of cytokines of vascular endothelial growth factor (VEGF), stromal derived factor-1 (SDF-1), interleukin-6 (IL-6) and regulated upon activation, normal T-cell expressed and secreted (RANTES) were measured in each vitreous sample obtained at PPV. Macular thickness obtained by optical coherence tomography was also monitored during clinical course.

Results

After the PRP, macular thickness in PRP-pretreated eye showed temporal increase. Vitreous levels of IL-6 and RANTES in PRP pre-treated eye were significantly higher than levels in control eyes (p = 0.013, p = 0.033). Although macular thickness in control was correlated to vitreous levels of VEGF and IL-6 (p = 0.022, p = 0.003), that in PRP-pretreated eye was closely correlated to IL-6 and RANTES (p = 0.002, p = 0.011). After the PPV, macular thickness in both eye groups improved, and there was no significant difference between both eye groups 3 months after the PPV.

Conclusions

In patients with high-risk PDR, PRP cause temporal worsening of macular edema linked with pro-inflammatory cytokines of IL-6 and RANTES, but not with VEGF and SDF-1. Thus, PRP-induced macular edema was caused by inflammation, while visual prognosis after PPV was not influenced by pretreatment of PRP.

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Acknowledgement

The authors thank Dr. Norio Sugimoto in Theranostic Instruments Research Laboratories for technical support of statistical analyses and useful comments, and also thank Dr Dee Worman in Edit Science Co. Ltd for English editing.

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None

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Authors

Corresponding author

Correspondence to Masahiko Shimura.

Additional information

This study was supported by 2007 scientific grants in aid for clinical research by NTT East Japan Tohoku Hospital to MS, and 2007 scientific grant in aid by The Eye Research Foundation for the Aged to MS.

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Shimura, M., Yasuda, K., Nakazawa, T. et al. Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 247, 1617–1624 (2009). https://doi.org/10.1007/s00417-009-1147-x

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  • DOI: https://doi.org/10.1007/s00417-009-1147-x

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