Skip to main content

Advertisement

SpringerLink
Log in

Relationship between angiographic and optical coherence tomographic (OCT) parameters for quantifying choroidal neovascular lesions

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To correlate the volume of various spaces on optical coherence tomography (OCT) with fluorescein angiographic (FA) parameters in neovascular age-related macular degeneration (AMD).

Methods

Sixty-five consecutive cases of active subfoveal choroidal neovascularization (CNV) associated with AMD were retrospectively collected. Area and greatest linear dimension of CNV lesion components were calculated on FA. Corresponding StratusOCT image sets were analyzed using custom software (termed OCTOR), which allows manual measurement of the volume of the neurosensory retina, subretinal fluid, subretinal tissue, and pigment epithelial detachment (PED).

Results

Area of occult CNV on FA correlated with PED (R = 0.62) and subretinal fluid (R = 0.28) volume and negatively with subretinal tissue volume (R = −0.26) on OCT. Area of classic CNV on FA correlated with subretinal tissue (R = 0.60) and retinal (R = 0.38) volume on OCT. Automated StratusOCT output values showed poorer correlations than manually calculated OCTOR values.

Conclusions

OCT features of CNV lesions as measured by manual quantitative subanalysis correlate better with angiographic parameters than values provided by the automated StratusOCT analysis. These measures may improve our understanding of the morphologic effects of CNV lesions and may facilitate the development of a hybrid FA and OCT-based classification system for future clinical trials, which more fully characterizes CNV lesions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Barbazetto I et al (2003) Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin: fluorescein angiographic guidelines for evaluation and treatment-TAP and VIP report No. 2. Arch Ophthalmol 121:1253–1268

    Article  CAS  PubMed  Google Scholar 

  2. Fung AE, Lalwani GA, Rosenfeld PJ et al (2007) An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol 143:566–583

    Article  CAS  PubMed  Google Scholar 

  3. Gross NE, Aizman A, Brucker A et al (2005) Nature and risk of neovascularization in the fellow eye of patients with unilateral retinal angiomatous proliferation. Retina 25:713–718

    Article  PubMed  Google Scholar 

  4. Joeres S, Tsong JW, Updike PG et al (2007) Reproducibility of quantitative optical coherence tomography sub-analysis in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 48:4300–4307

    Article  PubMed  Google Scholar 

  5. Joeres S, Kaplowitz K, Brubaker JW et al (2008) Quantitative comparison of optical coherence tomography after Pegaptanib or Bevacizumab in neovascular age-related macular degeneration. Ophthalmology 115:347–354

    Article  PubMed  Google Scholar 

  6. Keane PA, Liakopoulos S, Ongchin SC et al (2008) Quantitative subanalysis of optical coherence tomography after treatment with Ranibizumab for neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 49:3115–3120

    Article  PubMed  Google Scholar 

  7. Kozak I, Morrison VL, Clark TM et al (2008) Discrepancy between fluorescein angiography and optical coherence tomography in detection of macular disease. Retina 28:538–544

    Article  PubMed  Google Scholar 

  8. Laser photocoagulation of subfoveal neovascular lesions of age-related macular degeneration. Updated findings from two clinical trials. Macular Photocoagulation Study Group. Arch Ophthalmol 111:1200–1209

  9. Liakopoulos S, Ongchin S, Bansal A et al (2008) Quantitative optical coherence tomography findings in various subtypes of neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 49:5048–5054

    Article  PubMed  Google Scholar 

  10. Ray R, Stinnett SS, Jaffe GJ (2005) Evaluation of image artifact produced by optical coherence tomography of retinal pathology. Am J Ophthalmol 139:18–29

    Article  PubMed  Google Scholar 

  11. Sadda SR, Wu Z, Walsh AC et al (2006) Errors in retinal thickness measurements obtained by optical coherence tomography. Ophthalmology 113:285–293

    Article  PubMed  Google Scholar 

  12. Sadda SR, Joeres S, Wu Z et al (2007) Error correction and quantitative sub-analysis of optical coherence tomography data using computer-assisted grading. Invest Ophthalmol Vis Sci 48:839–848

    Article  PubMed  Google Scholar 

  13. Sandhu SS, Talks SJ (2005) Correlation of optical coherence tomography, with or without additional colour fundus photography, with stereo fundus fluorescein angiography in diagnosing choroidal neovascular membranes. Br J Ophthalmol 89:967–970

    Article  CAS  PubMed  Google Scholar 

  14. Soliman W, Sander B, Hasler PW et al (2008) Correlation between intraretinal changes in diabetic macular oedema seen in fluorescein angiography and optical coherence tomography. Acta Ophthalmol 86:34–39

    PubMed  Google Scholar 

  15. Talks J, Koshy Z, Chatzinikolas K (2007) Use of optical coherence tomography, fluorescein angiography and indocyanine green angiography in a screening clinic for wet age-related macular degeneration. Br J Ophthalmol 91:600–601

    Article  PubMed  Google Scholar 

  16. van Velthoven ME, de Smet MD, Schlingemann RO et al (2006) Added value of OCT in evaluating the presence of leakage in patients with age-related macular degeneration treated with PDT. Graefes Arch Clin Exp Ophthalmol 244:1119–1123

    Article  PubMed  Google Scholar 

  17. Van de Moere A, Sandhu SS, Talks SJ (2006) Correlation of optical coherence tomography and fundus fluorescein angiography following photodynamic therapy for choroidal neovascular membranes. Br J Ophthalmol 90:304–306

    Article  PubMed  Google Scholar 

  18. Yannuzzi LA, Negrao S, Iida T et al (2001) Retinal angiomatous proliferation in age-related macular degeneration. Retina 21:416–434

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA

    Srinivas R. Sadda, Sandra Liakopoulos, Pearse A. Keane, Sharel C. Ongchin, Sandeep Msutta, Karen T. Chang & Alexander C. Walsh

  2. Department of Vitreoretinal Surgery, Center of Ophthalmology, University of Cologne, Cologne, Germany

    Sandra Liakopoulos

  3. Doheny Eye Institute-DEI 3623, 1450 San Pablo Street, Los Angeles, CA, 90033, USA

    Srinivas R. Sadda

Authors
  1. Srinivas R. Sadda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sandra Liakopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pearse A. Keane
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sharel C. Ongchin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sandeep Msutta
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Karen T. Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Alexander C. Walsh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Srinivas R. Sadda.

Additional information

Results of this study were presented as a poster at the 106th DOG annual meeting in September 2009.

This study was supported in part by NIH Grant EY03040 and NEI Grant R01 EY014375.

Drs. Walsh and Sadda are co-inventors of Doheny intellectual property related to optical coherence tomography that has been licensed by Topcon Medical Systems and are members of the scientific advisory board for Heidelberg Engineering. However, it is not related to the article’s subject matter.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sadda, S.R., Liakopoulos, S., Keane, P.A. et al. Relationship between angiographic and optical coherence tomographic (OCT) parameters for quantifying choroidal neovascular lesions. Graefes Arch Clin Exp Ophthalmol 248, 175–184 (2010). https://doi.org/10.1007/s00417-009-1193-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-009-1193-4

Keywords

Search

Navigation