Short communicationThe NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltage-operated Ca2+ channels in rat cultured cortical neurons
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Cited by (35)
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil
2022, European Journal of Medicinal ChemistryCitation Excerpt :Eliprodil (2) is a less potent GluN2B NMDA receptor antagonist than ifenprodil [23], but has equally strong neuroprotective properties in animal models of cerebral ischemia [24]. Since eliprodil (2) inhibits voltage dependent Ca2+ channels, its neuroprotective properties may be due to the action as dual antagonist [25]. The synthesis of tropane analogs of type 6 started with Boc-protected tropanone 7 [26].
Retinal ischemia: Mechanisms of damage and potential therapeutic strategies
2004, Progress in Retinal and Eye ResearchInteractions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats
2000, PainCitation Excerpt :In contrast, it has been shown that NMDA receptor antagonists such as MK-801 block morphine tolerance to analgesia (Trujillo and Akil, 1991; Gutstein and Trujillo, 1993) in the spinal cord (Gutstein and Trujillo, 1993). NMDA receptors antagonists are known to block voltage-dependent calcium currents including N-type currents (Church et al., 1994; Biton et al., 1994). Our results with ziconotide suggest that inhibition of spinal N-type calcium channels is not involved in the effect of NMDA receptor antagonists on morphine tolerance.
The pharmacology of native N-methyl-D-aspartate receptor subtypes: Different receptors control the release of different striatal and spinal transmitters
1998, Progress in Neuro-Psychopharmacology and Biological Psychiatry