Pigment epithelial dystrophy in the dog

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Abstract

Central progressive retinal atrophy is a pigment epithelial dystrophy of dogs, apparently inherited as dominant with variable penetrance.

Initially, the pigment epithelial cells become hypertrophied in a small region in the posterior pole of the eye. As the disease progresses, the lesion enlarges until the entire pigment epithelial cell layer is involved. In addition to a lateral spread, the disease also undergoes progression within a given region. What is at first a lesion only of the pigment epithelium, at the end stage involves the entire retina as well. A classification based on the extent and degree of retinal involvement is put forth. In addition, the accumulation of autofluorescent pigment within the pigment epithelium is noted and some possible relationships of the pigment accumulation to photoreceptor degeneration are discussed.

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