Regular articleCyclosporine a impairs wound healing in rats
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The number of immune cells is lower in healthy oral mucosa compared to skin and does not increase after scarring
2015, Archives of Oral BiologyCitation Excerpt :The role of T-cells during wound healing is not well defined yet, although a few effects of these cells during repair have been described. T-cell suppression and depletion resulted in impaired wound healing, while enhancement of T-cell function increased wound strength and collagen deposition.10–12 Depending on the location, wounds can heal with different outcomes.
Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair
2013, BloodCitation Excerpt :One hypothesis is that increasing angiogenesis may increase repair rates, although it might also make the wound weaker and more susceptible to a second injury during repair. Interestingly, wounds in patients treated with cyclosporine were significantly weaker.41 Therefore, it is possible that the Wnt-Calcinuerin-Flt1 pathway identified here is used by macrophages to suppress wound angiogenesis and consequently increase the transient strength of the repairing wound.
Everolimus interferes with the inflammatory phase of healing in experimental colonic anastomoses
2011, Journal of Surgical ResearchCitation Excerpt :Impairment of postoperative wound healing is one major side effect of immunosuppressive drugs [1–16].
Perioperative Concerns for Transplant Recipients Undergoing Nontransplant Surgery
2006, Surgical Clinics of North AmericaCitation Excerpt :That being said, mycophenolic mofetil (Cellcept) has been shown in one large retrospective series of transplant wound complications to be associated with increased wound problems compared with azathioprine [33]. Although there is substantial experimental evidence that cyclosporine and tacrolimus impair wound healing [36,38,41], until recently, the agents have been considered indispensable in any postoperative transplantation regimen. As a result, little can be deduced about their relative potency in inhibiting wound healing.
Mycophenolate Mofetil Impairs the Integrity of Colonic Anastomosis
2006, Journal of Surgical ResearchThe role of the immune system in conjunctival wound healing after glaucoma surgery
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