Platelet-derived growth factor levels in wounds of diabetic rats
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2021, Seminars in Cell and Developmental BiologyCitation Excerpt :By contrast to healthy wounds in which pro-inflammatory macrophages drive vessel sprouting, the increased pro-inflammatory population in diabetic mouse wounds leads to a decrease in pro-angiogenic signals for sprouting (e.g. VEGF [105]). Unsurprisingly, these wounds also have decreased levels of pro-angiogenic signals for vessel maturation (ANG1 [106]) and pericyte recruitment (PDGF [107]), corresponding to key angiogenic processes at later wound repair stages. Furthermore, diabetic mouse wound models also have increased levels of some anti-angiogenic signals, such as ANG2 [108].
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