Elsevier

Metabolism

Volume 37, Issue 7, July 1988, Pages 611-613
Metabolism

Preliminary report
Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease

https://doi.org/10.1016/0026-0495(88)90076-5Get rights and content

Abstract

Thermostability of lymphocyte methylenetetrahydrofolate reductase (MTHFR) was determined in 21 patients aged less than 50 years with proven coronary artery disease, and in 21 age- and sex-matched controls without clinical evidence of vascular disease. The mean ± SD of residual activity after heat inactivation at 46°C for five minutes was 37.6% ± 5.6% in the controls. In contrast, patients with coronary artery disease could be divided into two subgroups. Fifteen of them had 38.1 ± 5.9% residual activity which was similar to that of the controls. In six of them the mean ± SD residual activity after heat inactivation was 13.6% ± 5.1% which was below 2 SD of the normal mean. These observations suggested that thermolabile MTHFR was associated with development of coronary artery disease.

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