Elsevier

Metabolism

Volume 44, Supplement 4, October 1995, Pages 72-75
Metabolism

The role of growth factors in the development of diabetic retinopathy

https://doi.org/10.1016/0026-0495(95)90224-4Get rights and content

Abstract

Proliferation of retinal blood vessels is one of the most striking features of advanced diabetic retinopathy. This feature has led to the conclusion that the normal balance of growth factors, which usually serves to keep angiogenesis in check, is disturbed in diabetic retinopathy. A considerable amount of work has been performed in the field of angiogenesis within the last decade. Much of this is applicable to diabetic eye disease, but due to the lack of an animal model, few studies have been performed directly on models of diabetic retinopathy. This review examines the literature as it relates to diabetic retinopathy.

References (58)

  • R Montesano et al.

    In vitro rapid organisation of endothelial cells into capillary-like networks is promoted by collagen matrices

    J Cell Biol

    (1983)
  • DE Ingber et al.

    Mechanochemical switching between growth and differentiation during fibroblast growth factor stimulated angiogenesis in vitro: Role of the extracellular matrix

    J Cell Biol

    (1989)
  • DE Ingber

    Fibronectin controls capillary endothelial cell growth by modulating cell shape

  • JR Williamson et al.

    Basement membrane abnormalities in diabetes mellitus: Relationship to clinical microangiopathy

    Diabetes Metab Rev

    (1988)
  • SS Tolsma et al.

    Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

    J Cell Biol

    (1993)
  • P Xia et al.

    Characterisation of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia

    Diabetes

    (1994)
  • T-S Lee et al.

    Activation of protein kinase C by elevation of glucose concentration: Proposal for a mechanism in the development of diabetic microvascular complications

  • T-S Lee et al.

    Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells

    J Clin Invest

    (1989)
  • PA Craven et al.

    Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: Possible mediation by glucose

    J Clin Invest

    (1989)
  • MJ Berridge

    Growth factors, oncogenes and inositol lipids

    Cancer Surv

    (1986)
  • WP Anderson et al.

    Altered subcellular distribution of protein kinase C: Possible role in tumor promotion and the regulation of cell growth: Relationship to changes in adenylate cyclase activity

    Adv Cyclic Nucleotide Protein Phosphorylation Res

    (1985)
  • HU Haring

    The insulin receptor: Signalling mechanism and contribution to the pathogenesis of insulin resistance

    Diabetologia

    (1991)
  • S Jacobs et al.

    Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin

  • M Brownlee et al.

    Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications

    N Engl J Med

    (1988)
  • M Kirstein et al.

    Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet derived growth factor: Role in vascular disease and aging

  • A Schröder et al.

    Activated monocytes and granulocytes, capillary non-perfusion, and neovascularisation in diabetic retinopathy

    Am J Pathol

    (1991)
  • M Klagsbrun et al.

    Regulators of angiogenesis

    Annu Rev Physiol

    (1991)
  • BM Glaser et al.

    Retinal pigment epithelial cells release an inhibitor of neovascularisation

    Arch Ophthalmol

    (1985)
  • HC Wong et al.

    Retinal pigment epithelial cells in culture produce retinal vascular mitogens

    Arch Ophthalmol

    (1988)
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