The role of growth factors in the development of diabetic retinopathy
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Cited by (27)
Ocular Angiogenesis
2008, Ocular TherapeuticsHyaluronan production regulation from porcine hyalocyte cell line by cytokines
2007, Experimental Eye ResearchCitation Excerpt :The cells of proliferative membranes are mainly composed of GFAP positive cells and they are classified into six types: pigment epithelial cells, astrocytes, macrophages, fibroblasts, cells of other types and unclassified cells (Yamashita et al., 1985, 1986). They are formed by the functions of various growth factors and cytokines include TGF-β1 and PDGF (D'Amore, 1994; Frank, 1994; Sharp, 1995; Casey and Li, 1997; Paster, 1998). These growth factors regulate HAS expression, HA is catalyzed by HAS and degradated by hyaluronidases (Toole, 2004).
Systemic IGF-I treatment inhibits cell death in diabetic rat retina
2006, Journal of Diabetes and its ComplicationsExpression and possible roles of activin A in proliferative vitreoretinal diseases
2000, Japanese Journal of OphthalmologyBasic fibroblast growth factor in patients with intermittent claudication: Results of a phase I trial
2000, Journal of the American College of CardiologyCitation Excerpt :We were able to show that two doses of 30 μg/kg of bFGF did not have appreciable effects on proteinuria or serum creatinine levels in our patients. Although diabetics were included, larger numbers of patients are needed before a deleterious effect on renal function can be safely ruled out in diabetics and in patients with proteinuria exceeding 200 mg/24 h. Endothelial growth factors have been implicated as mediators of intraocular neovascularization (25,26). In our study of patients with normal retinae at baseline and in individuals with mild to moderate nonproliferative retinopathy (three patients enrolled in the study had nonproliferative retinopathy), bFGF did not induce new vessel formation.
Elevated serum levels of soluble vascular cell adhesion molecule-1 in NIDDM patients with proliferative diabetic retinopathy
1998, Diabetes Research and Clinical Practice