Optic disc pallor: A false localizing sign☆
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Electrophysiology in neuro-ophthalmology
2021, Handbook of Clinical NeurologyCitation Excerpt :Visual symptoms and signs such as disc pallor and a RAPD are common to both optic nerve and retinal disease, and it can be difficult to distinguish between optic neuropathy and subtle or occult retinopathy or maculopathy, especially in the late or chronic phase (Sadun, 1990). Disc pallor has long been associated with cone dystrophy, the latter not always manifesting other visible or obvious fundoscopic signs of retinopathy (Newman, 1993; Fig. 5.8). Central or branch retinal artery occlusion presents acutely with retinal pallor but commonly evolves into disc pallor, at which stage it may be hard to determine if the patient had this or an ischemic optic neuropathy, or both (Khosla et al., 2004).
International federation of clinical neurophysiology: Recommendations for visual system testing
2010, Clinical NeurophysiologyCitation Excerpt :In carcinoma associated retinopathy (CAR), a paraneoplastic autoimmune disorder, the visual loss may be rapid (see below). Cone or cone rod dystrophies will often present with acuity loss due to central retinal cone involvement, and caution should be exercised in relation to the masquerade of cone dystrophy presenting with disc pallor but a macula that appears anatomically normal (e.g. Sadun, 1990; Newman, 1993). PERG or mfERG used in association with the PR-VEP will enable the differentiation from optic nerve disease.
Chapter 2 Is It a Neuro-Ophthalmic Problem? (If Not, What Else Could It Be?)
2008, Blue Books of NeurologyIncreasing Exotropia and Decreasing Vision in a School-aged Boy
2007, Survey of OphthalmologyCitation Excerpt :Patients with cone dystrophies and cone–rod dystrophies often present with bilateral, progressive visual loss associated with photophobia, hemiralopia (improved vision in darkness) and decreased color vision. Fundus examination may show optic disk pallor, telangiectasias of the optic nerve head, retinal vessel attenuation, retinal pigment epithelial changes, and a target retinopathy from retinal pigment epithelial atrophy in the macula.13,14,22 However, at presentation, patients may have isolated optic disk pallor or an apparently normal fundus examination.15,22
Chapter 14 Genetically determined disorders of retinal function
2005, Handbook of Clinical NeurophysiologyPattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis
2001, Progress in Retinal and Eye Research
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This work was supported in part by a departmental grant (Ophthalmology, Emory University) from Research To Prevent Blindness, Inc.