Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium
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Cited by (58)
Canine neuronal ceroid lipofuscinoses: Promising models for preclinical testing of therapeutic interventions
2017, Neurobiology of DiseaseCitation Excerpt :The pigment resembles ceroid and lipofuscin storage material (Katz and Robison, 2002; Seehafer and Pearce, 2006), hence the name of the disease. The term ceroid refers to intracellular autofluorescent material that accumulates in cells of various tissues as a result of pathological processes or nutritional deficiencies (Davidson et al., 1998; Katz et al., 1986; Katz et al., 1984; Katz and Robison, 2002; Katz et al., 1978; Sulzer et al., 2008). Lipofuscin, on the other hand, refers to autofluorescent lysosomal storage material that accumulates primarily in postmitotic cells as part of the normal process of senescence (Katz and Robison, 2002; Seehafer and Pearce, 2006).
Similar molecules spatially correlate with lipofuscin and N-retinylidene-N-retinylethanolamine in the mouse but not in the human retinal pigment epithelium
2013, Archives of Biochemistry and BiophysicsC20-D<inf>3</inf>-vitamin A slows lipofuscin accumulation and electrophysiological retinal degeneration in a mouse model of stargardt disease
2011, Journal of Biological ChemistryCitation Excerpt :The retinas were homogenized in butanol (100 μl), the homogenates were clarified through centrifugation and then analyzed directly using MS. Quantification of RPE autofluresence was performed as essentially described by Katz et al. (22). Briefly, under a 10× stereomicroscope with standard illumination, eyecups were dissected out, separated from the retina, and slits were made along the periphery so that they could lay flat.
Phospholipid meets all-Trans-retinal: The making of RPE bisretinoids
2010, Journal of Lipid ResearchCitation Excerpt :In addition, all-trans-retinal generated by retinol dehydrogenase activity in RPE is complexed to RGR (retinal G protein-coupled receptor) and is of low abundance (43). Evidence for the involvement of the visual cycle as the major source of RPE lipofuscin originated with experiments documenting that the deposition of lipofuscin granules and the presence of lipofuscin autofluorescence is dependent on dietary vitamin A (44, 45). Additionally, when the 11-cis- and all-trans-retinal chromophores of visual pigment are not generated, as in Rpe65−/− mice, RPE lipofuscin measured as fluorescence intensity is severely diminished (46) and the many lipofuscin chromophores absorbing in the visible range of the spectrum are absent (34, 47).
Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive stargardt disease
2009, Journal of Biological Chemistry