Test-tube simulated lipofuscinogenesis. Effect of oxidative stress on autophagocytotic degradation
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Cysteamine inhibits lysosomal oxidation of low density lipoprotein in human macrophages and reduces atherosclerosis in mice
2019, AtherosclerosisCitation Excerpt :Lysosomes contain catalytically active iron [22] and iron staining is common in human advanced atherosclerotic lesions and colocalises with ceroid [23]. This iron may be derived either by autophagy of organelles, together with their iron-containing proteins, or from the endocytosis of iron-containing proteins [61]. We tested if the lysosomal oxidation of SMase-LDL that had already accumulated in lysosomes could be inhibited using antioxidants that have access to lysosomes.
Mitochondrial quality control: Easy come, easy go
2015, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Mitochondrial membranes have also been suggested as a source for autophagosome membrane lipids, particularly as the mitochondria are the key site for synthesis of phosphatidylethanolamine needed for lipidation of LC3 [110,111]. During mitophagy, most of the membrane lipids are degraded in the lysosome, liberating free fatty acids [112]; this process may be disrupted in the presence of lipid peroxides, leading to accumulation of lipofuscin [113]. Classic approaches in monitoring mitochondrial turnover involved the use of radioactive isotope labeling of mitochondrial proteins [67], phospholipids [114], and heme groups [66].
Lysosomal dysfunction in muscle with special reference to glycogen storage disease type II
2003, Biochimica et Biophysica Acta - Molecular Basis of DiseaseOn the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes
1998, Mechanisms of Ageing and Development