Age-related changes of scleral hydration and sulfated glycosaminoglycans
References (37)
A colloid osmotic model of macromolecular aggregation to explain tissue water loss in aging
Exp. Gerontol.
(1986)- et al.
Interrelation between body composition and endocrine system in health elderly people
Mech. Ageing Dev.
(1984) The Eye
- et al.
Proteoglycans and collagen fibre organization in human corneoscleral tissue
Exp. Eye Res.
(1975) - et al.
Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene blue
Biochim. Biophys. Acta
(1986) - et al.
Age-related changes of sulfated proteoglycans in the normal human trabecular meshwork
Exp. Eye Res.
(1992) - et al.
Comparison of bovine corneal and scleral mucopolysaccharides
Biochim. Biophys. Acta
(1957) - et al.
Studies on keratosulfates
- et al.
Cartilage keratan sulfate: changes in chain length with aging
Biochem. Biophys. Acta
(1985) - et al.
Age related changes in sulfation of basement membrane
Exp. Gerontol.
(1983)
Corneal resistance to the flow of water after enzymatic digestion
Exp. Eye Res.
A hypothetical explanation for the aging of skin. Chronological alteration of the three-dimensional arrangement of collagen and elastin fibers in connective tissue
Am. J. Pathol.
Age related changes in elastic tissue of the human thoracic aorta
Atherosclerosis
Principles of Mammalian Aging
Connective tissue in aging lung
Gerontology
Aging of connective tissues
Front. Matrix Biol.
Physiological function of connective tissue polysaccharides
Physiol. Rev.
Variations in the intrinsic mechanical properties of human articular cartilage with age degeneration and water content
J. Bone Joint Surg.
Cited by (60)
Is the human sclera a tendon-like tissue? A structural and functional comparison
2022, Annals of AnatomyCitation Excerpt :However, there is a contribution from free chloride binding ligands, which explain the differential swelling of the corneoscleral tunic in response to changes in its ionic environment (Hodson, 1997; Huang and Meek, 1999). In a laboratory study, water content was found to be 71.6% ± 0.63% for human sclera and 69.5% ± 1.18% for porcine sclera (Brown et al., 1994; Rada et al., 2000). Tissue hydration state determined the permeability of the sclera to exogenous compounds.
Bioinorganic chemistry of open-angle glaucoma: A review
2020, Journal of Trace Elements in Medicine and BiologyScleral structure and biomechanics
2020, Progress in Retinal and Eye ResearchCitation Excerpt :In vitro swelling studies (Huang and Meek, 1999) determined the isoelectric point of the sclera (where the tissue swells least) to be at pH 4, with higher tissue hydrations achievable when the ionic strength of the bathing medium was lower. The sclera loses water as its ages (Brown et al., 1994; Rada et al., 2000), an effect which is suspected to be driven by associated changes in PG composition (see s4.1). Tissue hydration state is also important in determining the permeability of the sclera to exogenous compounds.
Scaffolds mimicking the native structure of tissues
2019, Handbook of Tissue Engineering Scaffolds: Volume OneThe dynamic sclera: Extracellular matrix remodeling in normal ocular growth and myopia development
2015, Experimental Eye ResearchThe effects of glycosaminoglycan degradation on the mechanical behavior of the posterior porcine sclera
2015, Acta BiomaterialiaCitation Excerpt :Their fixed charge density also creates attraction/repulsion forces among themselves and with collagen fibrils. As a result, the GAG content helps to determine the tissue hydration [32] by determining the number of polar sites for water binding and the space for free water uptake [33], as well as the tissue swelling pressure [34–36], which is highly dependent on hydration [37]. Hydration is believed to regulate the spacing between collagen fibrils in the ECM [38,39].