Original articleMast cell numbers and staining characteristics in the normal and allergic human conjunctiva☆
References (22)
- et al.
Ocular allergy and mast cell stabilisers
Surv Ophthalmol
(1986) - et al.
Heterogeneity of metachromatic cells in the human nose: significance of mucosal mast cells
J Allergy Clin Immunol
(1985) - et al.
Localization of tryptase to human cutaneous mast cells and keratinocytes by immunofluorescence and immunoperoxidase cytochemistry with monoclonal antitryptase antibody
J Allergy Clin Immunol
(1985) Beitrage zur kenntnis der Anilinfarbungen und ihrer Verwegnung in der mikroskopischen Technik
Arch Mikr Anat
(1876)Mast cell heterogeneity: the evolution of the concept of a specific mucosal mast cell
- et al.
Heterogeneity in mast cell populations
Clin Immunol Rev
(1985) - et al.
Human intestinal mucosal mast cells: evaluation of fixation and staining techniques
J Clin Pathol
(1981) - et al.
Two types of human mast cell that have distinct neutral protease compositions
- et al.
Human mast cell tryptase: a biochemical marker for mast cell degranulation
Biochem Soc Trans
(1989) - et al.
Tryptase from human pulmonary mast cells: purification and characterisation
J Biol Chem
(1981)
Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase
J Immunol
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Supported by a Wessex Regional Health Authority Clinical Research Award and grants from the Wessex Medical School Trust and the Iris Fund for the Prevention of Blindness.
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From the Southampton Eye Hospital, Southampton, England.
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From the University Department of Pathology, Southampton General Hospital, Southampton, England.
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Dr. A. F. Walls is a Wellcome Trust Research Fellow.
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Immnunopharmacology Group, Medicine I, Southampton General Hospital, Southampton, England.