Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

doi:10.1016/0092-8674(93)80065-M

Cell

Volume 75, Issue 2, 22 October 1993, Pages 229-240

https://doi.org/10.1016/0092-8674(93)80065-M Get rights and content

Summary

bcl-2 —/— mice complete embryonic development, but display growth retardation and early mortality postnatally. Hematopoiesis including lymphocyte differentiation is initially normal, but thymus and spleen undergo massive apoptotic involution. Thymocytes require an apoptotic signal to manifest accelerated cell death. Renal failure results from severe polycystic kidney disease characterized by dilated proximal and distal tubular segments and hyperproliferation of epithelium and interstitium. bcl-2 —/— mice turn gray with the second hair follicle cycle, implicating a defect in redox-regulated melanin synthesis. The abnormalities in these loss of function mice argue that Bcl-2 is a death repressor molecule functioning in an antioxidant pathway.

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Cell

ArticleBcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Summary

Cell

Cell

Dermatol. Clin.

Kidney Int.

Cell

Cell

Cell

J. Invest. Dermatol.

Adv. Genet.

Cell

Cell

Cell

Cell

Kidney Int.

Cell

J. Invest. Dermatol.

Congenital murine polycystic kidney disease. I. The ontogeny of tubular cyst formation

Pediatr. Nephrol.

Congenital murine polycystic kidney disease. II. Pathogenesis of tubular cyst formation

Pediatr. Nephrol.

Apoptotic cell death induced by c-myc is inhibited by bcl-2

Nature

Separation of pigmented and albino melanocytes and the concomitant evaluation of endogenous peroxide content using flow cytometry

Cytometry

Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor

Development

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors

Nature

Comparison of human polycystic and medullary cystic kidney disease with diphenylamine-induced cystic disease

Lab. Invest.

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Lab. Invest.

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Polycystic kidney disease

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

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J. Cell Biol.

Article
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair