Hydrogen peroxide-induced DNA damage in bovine lens epithelial cells
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2017, Bioorganic and Medicinal Chemistry LettersIonizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research
2016, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :Data from other studies not directly assessing the effects of IR exposure can also prove informative. For instance, when bovine LEC cell lines were treated with H2O2, the resulting oxidative stress induced extensive DNA damage within LECs [126]. The quantity of damage increased linearly with increasing H2O2 concentration, although no DSBs were observed as these are not induced by H2O2.
A novel carbohydrate derived compound FCP5 causes DNA strand breaks and oxidative modifications of DNA bases in cancer cells
2015, Chemico-Biological InteractionsCitation Excerpt :FCP5 increased DNA fragmentation in all studied cancer cells in a concentration dependent manner (Fig. 3). Since DNA strand breaks are often the result of increased oxidative stress [35], we investigated whether FCP5 causes oxidation of DNA. To avoid potential confusion caused by a high level of DNA breaks that could disrupt comet assay analysis, we chose the smallest toxic FCP5 concentration (0.1 mM).
Gene-environment interactions in ocular diseases
2009, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisIron metabolism in the eye: A review
2009, Experimental Eye ResearchCitation Excerpt :Iron has a central role in catalyzing free radical reactions leading to oxidative damage. Iron-catalyzed reactions have been linked to changes in lens crystallins (Garland, 1990; McDermott et al., 1988), lens DNA damage (Kleiman et al., 1990) and cataract formation (Garland, 1990; Levi et al., 1998; Truscott, 2005). Therefore, it was important to determine if iron levels and reactivity change in the lens during cataractogenesis.