Research reportDevelopmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil
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Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators
2012, Neurochemistry InternationalCitation Excerpt :The fourth class of NMDA receptor antagonists came from the compound ifenprodil (Fig. 3) (Carter et al., 1988) which binds at an interface between NTDs (Karakas et al., 2011). Ifenprodil displays a strong selectivity for the GluN1/GluN2B receptor (Williams, 1993) which explains the observation that ifenprodil is more effective early in CNS development (Zeevalk and Nicklas, 1992). This compound was followed by many derivatives that generally show a high degree of selectivity for GluN1/GluN2B receptors (Borza and Domany, 2006).
The pharmacology of native N-methyl-D-aspartate receptor subtypes: Different receptors control the release of different striatal and spinal transmitters
1998, Progress in Neuro-Psychopharmacology and Biological PsychiatryNeurotoxicity of Polyamines and Pharmacological Neuroprotection in Cultures of Rat Cerebellar Granule Cells
1997, Experimental NeurologyCa<sup>2+</sup> influx through glutamate receptor-associated channels in retina cells correlates with neuronal cell death
1996, European Journal of PharmacologyRegulation by neuroprotective factors of NMDA receptor mediated nitric oxide synthesis in the brain and retina
1994, Progress in Brain ResearchNew insight into the functional role of acetylcholine in developing embryonic rat retinal neurons
2002, Investigative Ophthalmology and Visual Science
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