Research paperLymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins
References (31)
- et al.
Contributions of host and donor T cells to the inflammatory process in murine lymphocytic choriomeningitis
Cell. Immunol.
(1988) - et al.
Dissection of an inflammatory process induced by CD8+ T cells
Immunol. Today
(1990) - et al.
Consequences of a single Ir-gene defect for the pathogenesis of lymphocytic choriomeningitis
Immunogenetics
(1985) - et al.
Cellular events in the lymph node and lung of mice with influenza: consequences of depleting CD4+ T cells
J. Immunol.
(1990) - et al.
Transgenic mice lacking class I MHC-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge
J. Exp. Med.
(1992) - et al.
Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice
Nature
(1991) - et al.
The virology and immunology of lymphocytic choriomeningitis virus infection
Adv. Immunol.
(1979) - et al.
Characterization of the murine T cell surface marker L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu3/T4 molecule
J. Immunol.
(1983) - et al.
Hybrid resistance modulates the inflammatory process induced by lymphocytic choriomeningitis virus-immune T cells
Immunology
(1986) - et al.
T cell mediated immunopathology in viral infections
Transplant. Rev.
(1974)
Genomic and biological variation among commonly used lymphocytic choriomengitis strains
J. Gen. Virol.
Clearance of influenza virus respiratory infection in mice lacking class-I-MHC-restricted CD8+ T cells
J. Exp. Med.
Peptide-induced conformational change of the class I heavy chain
Nature
Cell-surface expression of H-2Db requires N-linked glycans
Immunogenetics
Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression
J. Exp. Med.
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2016, Seminars in Cell and Developmental BiologyCitation Excerpt :T-cells release a number of cytokines capable of producing an illness response when injected centrally, including IL-6 and LIF [157,158]. In animals inoculated ICV with LCMV, anorexia and lethargy are maintained by MHC II restricted CD4+ cells [154]. Mice treated with anti-CD8 antibodies or HLA Class I knockout then infected with LCMV experienced nonlethal chronic wasting, losing approximately 25% body weight over the course of 32 days before recovering [154].
TNFRs and Control of Chronic LCMV Infection: Implications for Therapy
2015, Trends in ImmunologyCitation Excerpt :LCMV, a natural rodent pathogen, has provided valuable insights into these processes with implications for human disease [1,2]. Early control of LCMV is mediated primarily by CD8 T cells [3,4]. Late control of LCMV, as exemplified by LCMV clone (cl 13) or LCMV Docile, is achieved by a functionally exhausted – but still effective – CD8 T cell response as well as by neutralizing antibodies (nAb).
An intermediate dose of LCMV clone 13 causes prolonged morbidity that is maintained by CD4+ T cells
2012, VirologyCitation Excerpt :Therefore, IFNγ and TNFα have a role in inflammation, they do not individually influence wasting in our model. CD4+ T cells are known to play a role in morbidity following an LCMV infection (Doherty et al., 1993; Fung-Leung et al., 1991; Zajac et al., 1996; Zhou et al., 2009). Therefore we wanted to investigate if CD4+ T cells were impacting wasting in our model.
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