Nucleotide sequence of the DNA polymerase gene of herpes simplex virus type 2 and comparison with the type 1 counterpart
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Cited by (72)
DNA polymerases of herpesviruses and their inhibitors
2021, EnzymesCitation Excerpt :Amino acid substitutions conferring resistance of HSV to FOS and CDV also emerged in the viral DNA pol, and could lead to cross-resistance between antiviral agents. The DNA pols of HSV-1 and HSV-2 are encoded by the UL30 gene and are composed of 1235 and 1240 amino acids, respectively [86]. Amino acid substitutions in UL30 DNA pol conferring drug resistance are mainly distributed in the polymerase domain, i.e., palm (25.0/47.5%), fingers (25.0/22.5%) and thumb (21.5/2.5%) compared to the exonuclease (27.3/22.5%) and NH2-terminal (1.3/2.5%) domains for HSV-1/ HSV-2 [87].
Herpesvirus DNA polymerases: Structures, functions and inhibitors
2017, Virus ResearchCitation Excerpt :Alterations of repressive chromatin structure around the MIEP is associated with transcriptional activation that induces viral lytic IE gene expression and production of infectious virus in these cells (Poole and Sinclair, 2015). The HSV and HCMV DNA polymerases are multi-functional enzymes (1235 and 1242 amino acids for UL30 and UL54, respectively) (Heilbronn et al., 1987; Tsurumi et al., 1987) which possess a polymerase activity for extension of DNA primer chains (Lehman and Boehmer, 1999; Nishiyama et al., 1983), an intrinsic 3′-5′ exonuclease activity that removes the mismatched nucleotide from the primer DNA strand (Knopf, 1979; Nishiyama et al., 1983) as well as a ribonuclease (RNase) H activity (Crute and Lehman, 1989). In addition, the carboxyl terminal region of the UL30/UL54 catalytic subunit interacts with the UL42/UL44 accessory protein which enhances the processivity of DNA replication (Digard et al., 1993; Gottlieb et al., 1990; Loregian et al., 2004; Weisshart et al., 1994).
Herpesviruses and Toxoplasma gondii in orbital frontal cortex of psychiatric patients
2003, Schizophrenia Research