Autoantibody synthesis in salivary glands of Sjögren's syndrome patients
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Cited by (87)
Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration
2016, Journal of AutoimmunityCitation Excerpt :The mechanisms that control cell-type specific balance between methylation and demethylation activities need further exploration in pSS. The origin and mechanisms leading to production of anti-SSB/La Ab in pSS, although incompletely understood, involve a multistep process including (i) SSB overexpression in SGEC [31], (ii) SSB protein post-translational phosphorylation leading to its association with the HLA molecules in SGEC [32], an association between anti-SSB/La Ab and HLA-DR3 has been reported [33], (iii) presentation to the immune system, (iv) B cell activation, proliferation, local production of the anti-SSB/La Ab, (v) SGEC apoptosis leading to cell surface and apoptotic blebs redistribution of the autoantigens SSA/Ro and SSB/La [34,35] and finally (vi), in response to this autoamplification loop, anti-SSB/La Ab detection together with anti-SSA/Ro Ab in peripheral blood of pSS patients [36]. In agreement with this general scenario, SSB mRNA and protein upregulation were observed in MSG from pSS patients who were positive for anti-SSB/La Ab.
Autoantibodies in Sjögren's syndrome: Clinical presentation and regulatory mechanisms
2012, Presse MedicaleCitation Excerpt :Moreover, it has been indicated that some autoantibodies are produced in the immunopathological lesion. Notably, previous studies have demonstrated that anti-Ro/SSA and anti-La/SSB autoantibodies are enriched in saliva of pSS patients [80–82] while B cells infiltrating the salivary glands contain intracytoplasmic immunoglobulins with anti-Ro/SSA and anti-La/SSB activity [83,84]. Taken together, the affected salivary glands in SS appear to be a major site of autoantibody production.
Subgroups of Sjögren syndrome patients according to serological profiles
2012, Journal of AutoimmunityCitation Excerpt :Anti-Ro52, anti-Ro60 and anti-La autoantibody producing cells have been found in salivary gland biopsies from SS patients and their presence correlates strongly with the presence of autoantibodies in the serum [29]. In addition, autoantibodies to Ro and La have been detected both in whole saliva [30] and in parotid saliva [31] from SS patients, possibly indicating local antibody synthesis in salivary glands [30], although some researchers consider contamination due to leakage of anti-Ro/SSA and anti-La/SSB antibodies from blood into saliva a more likely explanation [31]. Furthermore, serum was shown to be significantly more sensitive than parotid saliva for the detection of Ro and La antibodies [31].
Cellular microRNAs (miRNAs) and Sjögren's syndrome: Candidate regulators of autoimmune response and autoantigen expression
2011, Journal of AutoimmunityCitation Excerpt :The autoimmune responses appear to take place in the affected salivary glands. In fact, saliva of SS patients has been shown to contain large amounts of autoantibodies [4], while B cells infiltrating the salivary glands contain intracytoplasmic immunoglobulins with autoantibody reactivity [5]. In addition, upregulated expression of Ro/SSA and La/SSB mRNA and proteins, as well as La/SSB redistribution in the cytoplasm and the cell membrane has been reported in the salivary gland epithelia of SS patients [2,3,6].
Induction of autoimmunity by pristane and other naturally occurring hydrocarbons
2009, Trends in ImmunologyB-cell depletion in autoimmune diseases. Advances in autoimmunity
2009, Autoimmunity ReviewsCitation Excerpt :It is a chronic lymphocytic inflammatory disorder characterized by xerostomia and keratoconjunctivitis sicca; there probably are important alterations in the humoral immunity that favor the development of the disease. Functional salivary and lachrymal glandular insufficiency in SS is associated with infiltration by mixed populations of B and T lymphocytes, often resembling germinal centers [27]. They may produce rheumatoid factor, anti-Ro, and/or anti-La. (