Original articleAssessment of optic disk blood flow in patients with open-angle glaucoma
Section snippets
Methods
In a prospective cross-sectional study, 90 eyes of 90 patients with open-angle glaucoma were studied. Open-angle glaucoma was diagnosed as the presence of optic disk damage and visual field defects and a history of untreated intraocular pressure of more than 21 mm Hg, as evidenced from at least three independent measurements. Exclusion criteria were diabetes mellitus, age-related macular degeneration, and untreated systemic hypertension defined as systolic blood pressure greater than 170 mm Hg
Results
There were no significant differences in age, gender, or systemic hemodynamics between the two study groups (Table 1). Intraocular pressure was higher in patients with glaucoma than in healthy control subjects.
Using scanning laser Doppler flowmetry in patients with open-angle glaucoma, 55 (61%) and 53 (59%) blood flow readings with a coefficient of variation of less than 20% were obtained at the neuroretinal rim and the cup, respectively. In healthy control subjects, 37 measurements (61%)
Discussion
The present study confirms previous reports that optic disk perfusion is significantly reduced in patients with primary open-angle glaucoma.6, 9, 10 It extends these findings in so far that optic disk perfusion abnormalities were observed with two independent techniques, namely scanning laser Doppler flowmetry and topical fundus pulsation measurement. In addition, the present study is the first to establish a relationship between pulsatile blood flow in the optic disk and microvascular flow in
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