Original articleComparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease☆
Section snippets
Methods
The study was designed to provide a cross-sectional comparison of RTA and OCT in a consecutive series of eyes with retinopathies affecting the macular thickness. The study protocol was approved and monitored by the Johns Hopkins University Joint Committee on Clinical Investigation. All participants engaged in an informed consent process and signed a written consent document before study procedures were carried out. The subject of this report is 55 eyes of 44 patients who were examined over a
Results
Fifty-five eyes from 44 patients with various retinal diseases were examined with OCT and RTA. The patients were aged 45 to 86 years (median, 68 years); 21 were male and 23 were female. In all 55 eyes it was possible to obtain OCT scans that were adequate for analysis, either automated or manual. RTA scans could not be obtained in 21 eyes primarily because of media opacities including mild corneal edema, dense cortical lens opacities, moderate-to-severe nuclear or posterior subcapsular lens
Case 1
An 86-year-old man was referred 7 months after removal of a cataract and implantation of an intraocular lens in the left eye (OS). Visual acuity measured 20/70 OS and slit lamp biomicroscopy revealed a thickened macula with cystic changes in the fovea (Figure 3A). Fluorescein angiography was typical for cystoid macular edema, with hyperfluorescence in the macula due to leakage and pooling of dye in a petaloid pattern (Figure 3B). Radial OCT scans illustrated localized thickening of the central
Discussion
In this study, we performed RTA and OCT on the same day in a series of eyes with macular diseases, including eyes that had been previously treated with surgery or laser. In the sample of eyes in which both tests were obtained, our data show that thickness measurements for the foveal region provided by both mapping systems are very similar. Most of the differences observed between OCT and RTA foveal thickness indices were below 50 μm and they could therefore be attributed almost entirely to the
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This work was supported by grants from Michael Panitch, the National Eye Institute (EY12693-01 [SV] and core grant P30EY1765), Research to Prevent Blindness (a Lew R. Wasserman Merit Award [PAC], and an unrestricted grant). PAC is the George S. and Dolores Dore Eccles Professor of Ophthalmology and Neuroscience.
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Ran Zeimer holds a patent on the Retinal Thickness Analyzer and is a consultant for Talia Technologies, Ltd, Neve Ilan, Israel. The Johns Hopkins University, in accordance with its conflict of interest policies, is managing the terms of this arrangement.