Original ArticlesAbnormal focal macular electroretinograms in eyes with idiopathic epimacular membrane☆
Section snippets
Methods
Focal electroretinograms, macular a and b waves, and oscillatory potentials were recorded prospectively from 30 consecutive patients with unilateral idiopathic epimacular membrane. The ages of the patients were 25 to 75 years (mean ± SD, 58.3 ± 10.5 years). Because our previous studies12, 13, 14 demonstrated wide interindividual variations in oscillatory potentials but a high correlation between the two eyes for all components, the normal fellow eye served as the control. The relative
Results
A comparison of the focal macular electroretinograms recorded from the normal fellow eyes with those from an age-matched control group (30 to 70 years, 50 men and 31 women) showed no significant difference in the amplitudes of the a and b waves, and the oscillatory potentials (a wave, P = .91; b wave, P = .69; oscillatory potentials [O1 + O2 + O3], P = .77). In the same groups, no significant difference was found for the implicit times for the same components (a wave, P = .75; b wave, P = .84;
Discussion
The results of our study can be summarized as follows: (1) The amplitudes of the a and b waves and the oscillatory potentials were significantly reduced, and the implicit times of these components were significantly prolonged. (2) The reduction of the b wave was significantly greater than that of the a wave, which resulted in a lower b/a ratio. (3) The reduction in the amplitude of oscillatory potentials was significantly greater than that of other two waves. These findings indicate substantial
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2014, OphthalmologyCitation Excerpt :Because metamorphopsia and aniseikonia have a similar development mechanism, aniseikonia also may be associated with inner retinal thickness. With the use of focal macular electroretinography, previous studies examined whether b-wave and oscillatory potentials were reduced more than a-wave in eyes with ERM and found a significant correlation between relative b-wave amplitude (affected/normal contralateral eye) and visual acuity.38,39 Judging from the findings of previous reports and our present study, it is considered that ERM damages the neurons in the inner retinal layers.
Clinical Electrophysiology
2012, Retina Fifth EditionStructural and functional predictors of visual outcome of epiretinal membrane surgery
2012, American Journal of OphthalmologyCitation Excerpt :This finding is in agreement with a previous study8 that reported that the decrease in retinal electrophysiologic response was not limited to the fovea but also involved the perifoveal area in ERM. Although previous reports have described changes in electrophysiologic responses (mfERG or fERG) and OCT findings after ERM surgery,7–11 the correlations between such parameters and visual prognosis remain controversial. Moschos and associates8 reported a significant increase in mfERG responses after ERM surgery.
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This study was supported by Grant-in-Aid No. 62480362 from the Ministry of Education, Science and Culture, Japan.