Acute follicular conjunctivitis caused by adenovirus type 34
Section snippets
Case 1
: In September 1997, a healthy 34-year-old unmarried man with no significant medical history presented with an acute onset of redness, irritation, and discharge of the left eye. He had had a sore throat for 2 weeks. Examination showed moderate acute follicular conjunctivitis (Figure 1) without left preauricular lymph node enlargement. The cornea showed no epithelial keratitis. No abnormality was observed in the uveal tract or fundus of this eye. The right eye was normal. Visual acuity was 20/20
Results
Conjunctival scrapings taken in the early stage of conjunctivitis showed a predominance of mononuclear cells in 75% of the specimens. A mixed mononuclear and polymorphonuclear cell response was seen in the remaining 25% of the specimens.
The virus was in both cases identified as adenovirus 34 by conventional neutralization and hemagglutination inhibition techniques, using 20 antibody units of antisera to prototypes 1 to 41. Only antiserum to type 34 neutralized the isolates. The clinical strains
Discussion
The human adenoviruses currently number 49 serotypes.11, 12 To date, adenovirus 34 has been isolated from renal transplant recipients5, 6 and from patients with AIDS.7 It is reported that an intermediate strain between adenovirus 34 and adenovirus 35, which was neutralized by both adenovirus 34 and adenovirus 35 antisera, was isolated from patients with acute conjunctivitis.13 However, that strain showed identical restriction patterns to adenovirus 35 prototype strain (Holden) with SmaI, BamHI,
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Cited by (17)
Assessment of clinical signs associated with adenoviral epidemic keratoconjunctivitis cases in southern Japan between 2011 and 2014
2019, Diagnostic Microbiology and Infectious DiseaseCitation Excerpt :Due to such overlap of clinical signs between these pathologies, some cases considered as possible EKC at the first visit were revised to a different diagnosis during the development and resolution of the infections. Despite cases by types 3, 4, 11 and 34 exhibited palpebral and bulbar conjunctival injections, the lack of chemosis and corneal epithelial complications led us to consider these infections as conjunctivitis; moreover, these types are more frequently related to acute hemorrhagic conjunctivitis (AHC) and pharyngoconjunctival fever (PCF) (Aoki et al. 1982; Uchio et al. 1999). Furthermore, the duration of the infections from onset to resolution by non-HAdV-D types (10.9 ± 2.96 days) was significantly shorter than infections by HAdV-D types (16.60 ± 7.82 days) (P < 2 × 10−4, t test).
ADENOVIRUSES
2009, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth EditionProbable donor-derived human adenovirus type 34 infection in 2 kidney transplant recipients from the same donor
2019, Open Forum Infectious Diseases