Long-term tamoxifen citrate use and potential ocular toxicity*
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Tamoxifen retinopathy
2023, Survey of OphthalmologyOcular Toxicity in Breast Cancer Management: Manual for The Oncologist
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2022, Survey of OphthalmologyCitation Excerpt :Color vision and visual fields (VF). Color discrimination appears to be slightly compromised in tamoxifen users.164,384,401 VF assessment with short wavelength automated perimetry (SWAP) revealed that tamoxifen influenced visual responses mediated by short wavelength sensitive cones, in the periphery as well as at fovea.125,127
The effect of sex on the mouse lens transcriptome
2021, Experimental Eye ResearchCitation Excerpt :The prevalent hypothesis in the literature suggests that the withdrawal of estrogen at menopause results in cataract due to a “rebound” effect on the lens (Zetterberg and Celojevic, 2015). This postulate is supported by epidemiological studies finding a correlation between hormonal replacement therapy of menopausal women and protection from cataract (Noran et al., 2007; Younan et al., 2002), while treatment of breast cancer patients with the anti-estrogen, tamoxifen, increases cataract risk (Gorin et al., 1998; Nelson et al., 2019). In other tissues, sex confers more differences on cells than can be explained by just differential exposure to sex hormones, including changes in DNA methylation (Hodes et al., 2017) and the expression of numerous autosomal genes (Arnold, 2019), even prior to embryonic sex determination (Lowe et al., 2015).
Tamoxifen maculopathy: The importance of screening and long follow-up
2020, Journal Francais d'Ophtalmologie
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This study was funded by grant U10CA37377 from the National Institutes of Health, National Cancer Institute, Bethesda, Maryland.