Original contributionImmunohistologic analysis of gastrointestinal and pulmonary carcinoid tumors
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2014, Journal of Thoracic OncologyCitation Excerpt :Significant differences in the Ki-67 LI distribution have been described in several studies between TC and AC,58–60,64–66,68,69,71,72,79 between LCNEC and SCLC,64 or across the entire spectrum of lung NE tumors,81 whereas other authors did not support this correlation at all56,70,75 or limited the failure to poorly differentiated NE tumors only.60 Proposed cutoff thresholds of Ki-67 LI ranged from 2.5 to approximately 30% for carcinoids,58,59,62,64–66,68,69,75,76,79,82 with two studies detecting 50% or more in few AC,68,70 whereas the separation of SCLC and LCNEC, if any,64 is of more limited clinical impact.1,86 In another study on 190 lung NE tumors published in an abstract form only, although there were differences in Ki-67 LI among diverse tumor categories, the incorporation of this marker as a primary criterion in the classification scheme of lung NE tumors was not further supported.85