Association of antiphospholipid antibodies with retinalvascular disease in systemic lupus erythematosus*
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Cited by (77)
The clinical presentation of systemic lupus erythematosus and laboratory diagnosis
2021, Lahita’s Systemic Lupus ErythematosusRetinal vasculitis: A framework and proposal for a classification system
2021, Survey of OphthalmologyCitation Excerpt :Notably, patients do not usually have an associated anterior uveitis or vitritis. Patients with SLE who have positive antiphospholipid (APL) antibodies are at the highest risk of developing retinal vascular occlusions and retinal ischemia, specifically frosted branch angiitis.12,80 Contrast it to the more common features of lupus retinopathy outlined previously; however, those with APL antibodies present as an occlusive retinopathy, with severe ischemia and vitreous hemorrhage, more consistent with a thrombotic microangiopathy.68
Take a look at the eyes in Systemic Lupus Erythematosus: A novel point of view
2019, Autoimmunity ReviewsOcular manifestations in Egyptian systemic lupus erythematosus patients and their relation with disease activity and anti-phospholipid antibodies
2018, Egyptian RheumatologistCitation Excerpt :Tolba et al., [25] in their work on 30 active SLE patients, 12 (40%) had retinopathy and SLEDAI score significantly correlated. A large percentage of SLE patients with retinal vasculitis have concomitant aPL antibodies including ACL and LAC [26] and presence of those antibodies are associated with more severe retinopathy and vascular occlusion [27]. Our study showed that SLE patients with ocular affection had significantly higher serum levels of ACL IgM and LAC and consumed complement than those without.
The role of ophthalmic imaging in central nervous system degeneration in systemic lupus erythematosus
2018, Autoimmunity ReviewsCitation Excerpt :Retinal vasculitis, affecting both veins and arterioles, is a much rarer presentation with a significantly worse prognosis than microangiopathy. The finding of retinal vasculitis correlates with anti-phospholipid syndrome as well as with the presence of CNS vasculitis [56,66]. Histopathologic specimens show fibrinoid change with thrombus formation without a true arteritis [67].
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