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2022, International Journal of Biological MacromoleculesCitation Excerpt :It has been reported that mammalian cells prefer to adhere and proliferate on the surface with moderate hydrophilicity with a water contact angle in the range of 50–70 °C [105]. In addition, some serum proteins, such as fibronectin and vitronectin, which are well known to play an important role in cell adhesion, are more susceptible to moderate surface wetting [106]. The hydrophilicity influences not only the amount and type of serum protein adsorption but also the conformation of these proteins on the surface of the scaffolds, which in turn affects the degree of cell adhesion [107].
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