Ten-year postoperative results of penetrating keratoplasty☆
Section snippets
Methods
Enrollment consists of 500 consecutive patients who had penetrating keratoplasty between 1976 and 1986 by 1 surgeon (WMB). To make each graft an independent observation, 36 repeat grafts of eyes that previously were grafted in the study and 70 fellow eyes of bilateral cases were excluded. This left 394 grafts in 394 patients. There were 143 males and 251 females; the age at keratoplasty ranged from 3 to 94 years (62 ± 20 years, mean ± standard deviation). The distribution of preoperative
Results
One hundred nineteen patients returned for their 10-year postoperative examinations. The mean postoperative time was 10 years (range, 8.1–11.3 years). By the 10-year examination, 68 grafts were known to have failed and 80 patients were known to have died. One hundred nineteen patients represent 48% of the clear grafts available for follow-up (Table 3).
Of the 119 specular microscopic examinations performed at 10 years, 2 photographs produced images that were not sufficiently clear to allow for
Discussion
Several points need to be made regarding our data evaluation. First, when a large number of comparisons are made, the chance of reporting a type I error (a false-positive) is high. Therefore, more confidence should be placed in differences of higher statistical significance (i.e., those with P ≤ 0.01). Second, the results of nonrandomized studies such as this one are not as powerful or predictive as the results of randomized controlled studies. Third, when comparing the groups with regard to
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Supported in part by National Institutes of Health research grant EY 02037; an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York; and the Mayo Foundation, Rochester, Minnesota.