Vascular endothelial growth factor upregulation in human central retinal vein occlusion1
Section snippets
Materials and methods
The files of the F.C. Blodi Eye Pathology Laboratory at the University of Iowa were searched for paraffin blocks of surgically enucleated eyes with the clinical and histopathologic diagnoses of CRVO and NVG. Cases were excluded if the eyes were phthisical or were complicated by endophthalmitis. Most important, no postmortem specimens were included in this study. Ten eyes were available for study. Five eyes with choroidal or ciliary body melanoma, but with no detectable NV, were analyzed in
Results
The clinical and histologic details of the ten patients included in the study are summarized in Table 1. There were nine women and one man, 70 to 92 years of age (average, 83 years), all with CRVO. There were five right eyes and five left eyes. All were enucleated because of blindness and painful because of NVG. In six of the eyes, vision of “no light perception” was documented. Histologically, all eyes had CRVO and NVG. In these eyes, intraocular hemorrhages were found: in five, anterior
Discussion
The VEGF mRNA expression was upregulated in experimental retinal vein occlusion in rabbits,9 monkeys,14, 16 and murine model.17 We present here, to our knowledge for the first time upregulated expression of VEGF mRNA in a series of human retina with CRVO. Our results, showing that VEGF is upregulated in different layers of the retina in different patients, can be explained by the assumption that VEGF in CRVO is upregulated in response to retinal hypoxia, and in different eyes, different
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The authors have no proprietary interest in any of the materials used in this study.