Lymphoproliferative lesions of the ocular adnexa: Analysis of 112 cases
Section snippets
Tissue samples
One hundred twelve cases of lymphoid proliferation of the ocular adnexa in 112 patients were collected from the consultation files of the Pathology Departments of Universitätsklinikum Benjamin Franklin, Berlin, Germany, and of Western Infirmary, Glasgow, Scotland. Patients with inflammatory pseudotumor or lymphoid proliferations of the choroid, vitreous, or retina were excluded. The majority of the tissue biopsy specimens had been fixed in 10% formaldehyde solution and embedded in paraffin;
Clinical features and anatomic distribution
The patient group consisted of 79 females and 32 males in total with an age range of 14 to 91 years; median, 61 years (Fig 1). There was no significant age difference between the patients diagnosed with RLH and those with lymphoma (median age, 59 and 61 years, respectively) (Fig 1). None of the patients were suffering from Sjögren’s syndrome, Wegener’s granulomatosis, or Mikulicz syndrome.
The ocular adnexal lymphoid proliferations were distributed as follows: orbit in 52 (46%) with involvement
Discussion
Benign and malignant lymphoid proliferations of the ocular adnexa cannot be diagnosed accurately on the basis of clinical or radiologic criteria3, 22, 34, 35: the distinction often requires extensive histomorphologic, immunophenotypical, and molecular biologic analyses. In the current study, the majority of the lymphoproliferative lesions of the ocular adnexa could be divided into two groups—RLH or lymphoma—using conventional histology and immunohistochemistry. A gray zone of so-called
Acknowledgements
The authors thank the following pathologists and clinicians for their cooperation as well as their provision of access to patient records: Dr. D. Bauer-Matyas, Dr. N. Bechrakis, Prof. Bleckmann, Prof. S. Blumcke, Dr. F. Dallenbach, Dr. W. Due, Prof. M. H. Foerster, Prof. P. Grote, Prof. C. Hartmann, Priv. Doz., Dr. Hamisch, Dr S. Klebe, Prof. J. Kunz, Priv. Doz. G. Jautzke, Prof. L. D. Leder, Priv. Doz., U. Pleyer, and Dr. A. Walkow.
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