Outcomes in anterior uveitis associated with the HLA-B27 haplotype
Section snippets
Patients and methods
The clinical records of all patients with anterior uveitis seen at the Immunology & Uveitis Service, Massachusetts Eye & Ear Infirmary, between January 1982 and December 1993 were analyzed throughout patients’ entire follow-up and the following data were obtained: gender, race, age at presentation, age at onset of uveitis, follow-up time, clinical diagnosis or systemic disease association or both, clinical presentation, number and duration of recurrent inflammatory attacks, prevalence of severe
Results
A total of 191 consecutive patients, representing 28.2% of patients with anterior uveitis, referred to our service tested HLA-B27 positive and had no other primary ocular diagnosis and/or systemic disease association other than seronegative spondyloarthropathy or inflammatory bowel disease or both. Seventy-two patients (122 eyes) tested HLA-B27 negative and suffered from anterior uveitis of unknown etiology (idiopathic). The HLA-B27-positive group was further divided into 97 (50.8%) patients
Discussion
Anterior uveitis is the most common form of uveitis, and its association with the HLA-B27 haplotype in the white population has been estimated to be approximately 50%.14, 15 Patients with HLA-B27-positive anterior uveitis frequently present with unilateral or bilateral alternating, nongranulomatous, recurrent iridocyclitis in association with nonspecific arthritic symptoms or with a seronegative spondyloarthropathy.9 These clinical characteristics have made this group of patients
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