Detection of color vision defects in chloroquine retinopathy1
Section snippets
Patients
Patients were recruited consecutively during routine ophthalmologic screening visits in a single practice. All eligible patients were required to have at least 20/80 best-corrected visual acuity (BCVA) to see the color plates. In addition, patients were excluded if they had any conditions that may contribute to possible color vision defects. These conditions included systemic and local retinopathy such as diabetic retinopathy, sickle cell retinopathy, central serous retinopathy, retinitis
Detection of color vision defects
Figure 1 shows the distribution of patients in both groups failing each color vision test. Two patients in the retinopathy group passed all the tests. Of the 28 patients who showed a color defect, 2 failed only 1 test, which was the SPP-2 in both cases. The other 26 patients failed more than 1 test, which included the SPP-2 in all cases and at least 1 other color vision test. In contrast, only 5 of 25 patients in the control group failed at least 1 test. Two patients failed only the Dsat-15,
Discussion
Color vision is often not a standard part of routine screening of patients at risk of developing chloroquine retinopathy because of conflicting reports in the literature. Earlier studies have suggested color vision may be abnormal, but none have determined the sensitivity or specificity of the color vision tests for detection of toxicity. This study identified the common color vision defects seen in chloroquine retinopathy and compared the sensitivity and specificity of six clinical color
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The authors have no financial interests in the color vision tests reported in this article.