Focal Adhesions and Cell-Matrix Interactions

https://doi.org/10.1016/S0174-173X(88)80027-XGet rights and content

Abstract

Focal adhesions are areas of cell surfaces where specializations of cytoskeletal,membrane and extracellular components combine to produce stable cell-matrix interactions. The morphology of these adhesions and the components identified in them are discussed together with possible mechanisms of their formation.

References (219)

  • FoxJ.E.B. et al.

    Identification of two proteins (actinbinding protein and P235) that are hydrolyzed by endogenous Ca++-dependent protease during platelet aggregation

    J. Biol. Chem.

    (1985)
  • FurchtL.T. et al.

    Trypsin induced coordinate alterations in cell shape, cytoskeleton and intrinsic membrane structure of contact-inhibited cells

    Exp. Cell Res.

    (1978)
  • GeigerB.

    A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells

    Cell

    (1979)
  • GeigerB.

    Membrane- cytoskeleton interaction

    Biochim. Biophys. Acta

    (1983)
  • GiancottiF.G. et al.

    A 135,000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion

    Exp. Cell Res.

    (1986)
  • GiancottiF.G. et al.

    Cleavage of a 135KD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin

    Exp. Cell Res.

    (1985)
  • GoldbergB.

    Binding of soluble type I collagen molecules to the fibroblast plasma membrane

    Cell

    (1979)
  • GrinnellF.

    Cellular adhesiveness and extracellular substrata

    Int. Rev. Cytol.

    (1978)
  • GrinnellF.

    Visualization of cell substratum adhesion plaques by antibody exclusion

    Cell Biol. Int. Rep.

    (1980)
  • GrinnellF. et al.

    Initial adhesion of human fibroblasts in serum-free medium: possible role of secreted fibronectin

    Cell

    (1979)
  • GrinnellF. et al.

    Induction of cell spreading by substratum-adsorbed ligands directed against the cell surface

    Exp. Cell Res.

    (1978)
  • AbercrombieM. et al.

    The shape and movement of fibroblasts in culture

  • AplinJ.D. et al.

    Cell adhesion on model substrata: threshold effects and receptor modulation

    J. Cell Sci.

    (1981)
  • AshJ.F. et al.

    Concanavalin-A-induced transmembrane linkage of concanavalin A surface receptors to intracellular myosin-containing filaments

    Proc. Natl. Acad. Sci. USA

    (1976)
  • AshJ.F. et al.

    Antibody-induced linkages of plasma membrane proteins to intracellular actomyosin-containing filaments in cultured fibroblasts

    Proc. Natl. Acad. Sci. USA

    (1977)
  • AvnurA. et al.

    The removal of extracellular fibronectin from areas of cell-substratum contact

    Cell

    (1981)
  • BadleyR.A. et al.

    Comparison of the cell cytoskeleton in migratory and stationary chick fibroblasts

    J. Muscle Res. and Cell Motil.

    (1980)
  • BadleyR.A. et al.

    Cooperativity of Concanavalin A patching and its influence on cytoskeleton changes in fibroblast rounding and detachment

    J. Cell Sci.

    (1981)
  • BadleyR.A. et al.

    Cytoskeleton changes in fibroblast adhesion and detachment

    J. Cell Sci.

    (1980)
  • BaetscherM. et al.

    Vitronectin at sites of cell-substrate contact in cultures of rat myotubes

    J. Cell Biol.

    (1986)
  • BarnesD. et al.

    Effects of a serum spreading factor on growth and morphology of cells in serum-free medium

    J. Supramol. Struct.

    (1980)
  • BarnesD.W. et al.

    Characterization of human serum spreading factor with monoclonal antibody

    Proc. Natl. Acad. Sci. USA

    (1983)
  • BeckerleM.C.

    Identification of a new protein localized at sites of cell-substrate adhesion

    J. Cell Biol.

    (1986)
  • BeckerleM.C. et al.

    Demonstration of a relationship between talin and P235. A major substrate of the calcium-dependent protease in platelets

    J. Cell Biol.

    (1986)
  • Bereiter-HahnJ. et al.

    Quantitative reflection contrast microscopy of living cells

    J. Cell Biol.

    (1979)
  • BergmannJ.E. et al.

    Membrane insertion at the leading edge of motile fibroblasts

    Proc. Natl. Acad. Sci. USA

    (1983)
  • BerlinR.D. et al.

    Analagous ultrastructure and surface properties during capping and phagocytosis in leukocytes

    J. Cell Biol.

    (1978)
  • BoucautJ.-C. et al.

    Biologically active synthetic peptides as probes of embryonic development: A competitive peptide inhibitor of fibronectin function inhibits gastrulation in am

    J. Cell Biol.

    (1984)
  • BourguignonL.Y.W. et al.

    Transmembrane interactions and the mechanism of capping of surface receptors by their specific ligands

    Proc. Natl. Acad. Sci. USA

    (1977)
  • BourguignonL.Y.W. et al.

    Lymphoma Thy-1 glycoprotein is linked to the cytoskeleton via a 4.1-like protein

    J. Cell Biol.

    (1986)
  • BourguignonL.Y.W. et al.

    The capping of lymphocytes and other cells, studied by an improved method for immunofluorescence staining of frozen sections

    J. Cell Physiol.

    (1978)
  • BrennanM.J. et al.

    Effect of a proteoglycan produced by rat tumor cells on their adhesion to fibronectin or collagen substrata

    Cancer Res.

    (1983)
  • BretscherA. et al.

    Fimbrin, a new microfilament-,associated protein present in microvilli and other cell surface structures

    J. Cell Biol.

    (1980)
  • BretscherM.S.

    Distribution of receptors for transferrin and low density lipoprotein on the surface of giant HeLa cells

    Proc. Natl. Acad. Sci. USA

    (1983)
  • BrinkleyB.R. et al.

    Cytoplasmic microtubules in normal and transformed cells in culture: analysis of tubulin immunofluorescence

    Proc. Natl. Acad. Sci. USA

    (1975)
  • BurridgeK.

    Substrate adhesions in normal and transformed fibroblasts: Organization and regulation of cytoskeletal, membrane and extracellular matrix components at focal

    Cancer Rev.

    (1986)
  • BurridgeK. et al.

    A new protein of adhesion plaques and ruffling membranes

    J. Cell Biol.

    (1983)
  • ByersH.R. et al.

    Stress fibers in situ: Immunofluorescent visualization with antiactin, antimyosin, and anti -alpha-actinin

    J. Cell Biol.

    (1982)
  • ByersH.R. et al.

    Organization and function of stress fibers in vitro and in situ: a review

    Cell Muscle Motil.

    (1984)
  • CarterW.G. et al.

    Studies on cell adhesion and recognition. II. The kinetics of cell adhesion and cell spreading on surfaces coated with carbohydrate reactive proteins (glycosi

    J. Cell Biol.

    (1981)
  • Cited by (0)

    a

    Dr. Anne Woods, Department of Cell Biology and Anatomy, Buris R. Boshell Diabetes Research and Education Building, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

    View full text