Elsevier

Neuroscience Letters

Volume 287, Issue 3, 30 June 2000, Pages 171-174
Neuroscience Letters

Murine macrophages stimulated with central and peripheral nervous system myelin or purified myelin proteins release inflammatory products

https://doi.org/10.1016/S0304-3940(00)01184-8Get rights and content

Abstract

Macrophage inflammatory products including tumor necrosis factor (TNF) and interleukin-12/p40 are implicated in demyelinating diseases such as multiple sclerosis (MS), Guillain–Barré syndrome, and animal models experimental autoimmune encephalomyelitis and neuritis. The macrophage product angiotensin converting enzyme (ACE) is released during inflammation. ACE can also be elevated in MS. We investigated the ability of central (CNS) and peripheral nervous system (PNS) myelin to stimulate TNF, interleukin-12, and ACE production by murine macrophages. Both CNS and PNS myelin and purified myelin basic protein and P2 protein induced release of these products. Direct stimulation by myelin may represent a mechanism of inducing release of macrophage products in inflammatory demyelination or neural injury.

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Acknowledgements

Supported by NIH grant K11HD-01049 and by a grant from EMDO Foundation to C.S.C. We thank Dr A. Rostami for the anti-P2 antibody and Dr G. Trinchieri for helpful discussions.

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