7Phytoestrogens and inhibition of angiogenesis
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2023, Pathology Research and PracticeThe effects of fisetin on bone and cartilage: A systematic review
2022, Pharmacological ResearchCitation Excerpt :Natural compounds derived from plants with various physiological activities have been the target of much research, and in recent years, therapeutic effects of flavonoids such as quercetin, kaempferol and galangin, which are abundant in fruits, on osteoporosis and OA have been reported [21–23]. Among the wide variety of flavonoids, fisetin (3,7,3′,4′-tetrahydroxyflavone) has attracted a great deal of attention in the age-related bone and cartilage area, as fisetin has been reported to have not only many biological activities such as anti-oxidant [24], anti-inflammatory [25,26], anti-angiogenic [27], and anti-tumorigenic effects [28,29], but also an inhibitory effect on cellular senescence, a biological process that may play a key role in inflammation and aging [30]. In bone, it has been shown to have an inhibitory effect on bone loss through suppression of osteoclast differentiation [31] and activation of osteoblasts [32].
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2018, Studies in Natural Products ChemistryFisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice
2017, International ImmunopharmacologyCitation Excerpt :Fisetin (3,7,3′,4′-tetrahydroxyflavone) is a polyphenol and naturally occurring flavonoid that is abundantly present in several fruits and vegetables, such as persimmons, mangoes, grapes, apples, strawberries, peaches, cucumbers, onions and tomatoes [11]. Accumulating evidence indicates that fisetin has wide varieties of biological activities, including antioxidant [12], anti-inflammatory [13], anti-angiogenic [14] and anti-tumor activities [15]. Previous studies have reported that fisetin inhibited lipopolysaccharide (LPS)-induced pro-inflammatory cytokine release and activation of macrophages [16].