Origin, maturation and antigen presenting function of dendritic cells

doi:10.1016/S0952-7915(97)80153-7

Current Opinion in Immunology

Volume 9, Issue 1, February 1997, Pages 10-16

https://doi.org/10.1016/S0952-7915(97)80153-7 Get rights and content

Abstract

Dendritic cells are cells specialized for antigen capture, migration and T cell stimulation. Recent advances have been made in understanding their origin, their heterogeneity, the mechanism of antigen uptake, and the signals that induce their migration and maturation into immunostimulatory antigen-presenting cells. Dendritic cells represent the natural adjuvants for T cell responses and their therapeutic exploitation in the near future is foreseen.

References (75)

F Sallusto et al.
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
J Exp Med
(1994)
JH Peters et al.
Dendritic cells: from ontogenetic orphans to myelomonocytic descendants
Immunol Today
(1996)
LJ Zhou et al.
CD14⁺ blood monocytes can differentiate into functionally mature CD83⁺ dendritic cells
Proc Natl Acad Sci USA
(1996)
A Galy et al.
Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset
Immunity
(1995)
E Maraskowsky et al.
The effect of Flt3 ligand and/or c-Kit ligand on the generation of dendritic cells from human CD34⁺ bone marrow
Blood
(1995)
C Reis e Sousa et al.
Phagocytosis of an antigen by Langerhans cells in vitro
J Exp Med
(1993)
CC Norbury et al.
Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages
Immunity
(1995)
H Stossel et al.
Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cell
J Exp Med
(1990)
V Pinet et al.
Antigen presentation mediated by recycling of surface HLA-DR molecules
Nature
(1995)
TA Springer
Adhesion receptors of the immune system
Nature
(1990)

FG Snijdewint et al.

Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes

J Immunol

(1993)

RM Steinman

The dendritic cell system and its role in immunogenicity

Annu Rev Immunol

(1991)

K Inaba et al.

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

J Exp Med

(1992)

K Inaba et al.

Identification of proliferating dendritic cell precursors in mouse blood

J Exp Med

(1992)

K Inaba et al.

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow

Proc Natl Acad Sci USA

(1993)

C Caux et al.

GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells

Nature

(1992)

C Caux et al.

CD34⁺ hematopoietic progenitors from human core blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF α

J Exp Med

(1996)

P Szabolcs et al.

Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate

Blood

(1996)

N Romani et al.

Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability

J Immunol Methods

(1996)

L Piemonti et al.

IL-13 supports differentiation of dendritic cells from circulating precursors in concert with GM-CSF

Eur Cytokine Netw

(1995)

A Bender et al.

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

J Immunol Methods

(1996)

C Ardavin et al.

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

Nature

(1993)

C Marquez et al.

The development of T and non-T cell lineages from CD34⁺ human thymic precursors can be traced by the differential expression of CD44

J Exp Med

(1995)

D Saunders et al.

Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte-macrophage colony stimulating factor

J Exp Med

(1996)

G Suss et al.

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis

J Exp Med

(1996)

P Szabolcs et al.

Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34⁺ bone marrow precursors cultured with c-Kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha

J Immunol

(1995)

S Siena et al.

Massive ex vivo generation of functional dendritic cells from mobilized CD34⁺ blood progenitors for anti cancer therapy

Exp Hematol

(1995)

D Metcalf et al.

Effects of excess GM-CSF levels on hematopoiesis and leukemia development in GM-CSF/macs 41 double transgenic mice

Leukemia

(1996)

E Maraskowsky et al.

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified

J Exp Med

(1996)

RM Steinman et al.

The endocytic activity of dendritic cells [comment]

J Exp Med

(1995)

F Sallusto et al.

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products [see comments]

J Exp Med

(1995)

PD Stahl

The mannose receptor and other macrophage lectins

Curr Opin Immunol

(1992)

W Jiang et al.

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

Nature

(1995)

GC Mudde et al.

IgE: an immunoglobulin specialized in antigen capture? [see comments]

Immunol Today

(1990)

T Bieber et al.

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (FceRI)

J Exp Med

(1992)

D Maurer et al.

The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation

J Immunol

(1995)

KL Rock

A new foreign policy: MHC class I molecules monitor the outside world

Immunol Today

(1996)

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Origin, maturation and antigen presenting function of dendritic cells

Abstract

J Exp Med

Immunol Today

Proc Natl Acad Sci USA

Immunity

Blood

J Exp Med

Immunity

J Exp Med

Nature

Nature

J Immunol

The dendritic cell system and its role in immunogenicity

Annu Rev Immunol

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

J Exp Med

Identification of proliferating dendritic cell precursors in mouse blood

J Exp Med

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow

Proc Natl Acad Sci USA

GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells

Nature

CD34+ hematopoietic progenitors from human core blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF α

J Exp Med

Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate

Blood

Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability

J Immunol Methods

IL-13 supports differentiation of dendritic cells from circulating precursors in concert with GM-CSF

Eur Cytokine Netw

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

J Immunol Methods

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

Nature

The development of T and non-T cell lineages from CD34+ human thymic precursors can be traced by the differential expression of CD44

J Exp Med

Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte-macrophage colony stimulating factor

J Exp Med

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis

J Exp Med

Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-Kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha

J Immunol

Massive ex vivo generation of functional dendritic cells from mobilized CD34+ blood progenitors for anti cancer therapy

Exp Hematol

Effects of excess GM-CSF levels on hematopoiesis and leukemia development in GM-CSF/macs 41 double transgenic mice

Leukemia

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified

J Exp Med

The endocytic activity of dendritic cells [comment]

J Exp Med

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products [see comments]

J Exp Med

The mannose receptor and other macrophage lectins

Curr Opin Immunol

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

Nature

IgE: an immunoglobulin specialized in antigen capture? [see comments]

Immunol Today

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (FceRI)

J Exp Med

The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation

J Immunol

A new foreign policy: MHC class I molecules monitor the outside world

Immunol Today

CD34⁺ hematopoietic progenitors from human core blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF α

The development of T and non-T cell lineages from CD34⁺ human thymic precursors can be traced by the differential expression of CD44

Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34⁺ bone marrow precursors cultured with c-Kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha

Massive ex vivo generation of functional dendritic cells from mobilized CD34⁺ blood progenitors for anti cancer therapy