Brief reportIndocyanine green induces apoptosis in human retinal pigment epithelial cells☆
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Cited by (68)
Drugs Used in Ophthalmology
2020, Drug-Induced Ocular Side Effects, Eigtht EditionEffect of brilliant Blue-G on cellular stress response in retinal pigment epithelial cells: In vitro
2019, Experimental Eye ResearchCitation Excerpt :Among the various dyes used, indocyanine green (ICG) has the highest affinity for ILM. However, several studies have documented toxicity of ICG (Enaida et al., 2002; Rezai et al., 2004; Sippy et al., 2001). Brilliant Blue-G (BBG) dye, a triphenylmethane dye which selectively stains the ILM was introduced in 2006 by Enaida et al. (Enaida et al., 2006a, 2006b).
Part 7 - Drug-induced ocular side effects
2014, Drug-Induced Ocular Side Effects: Clinical Ocular ToxicologyChromovitrectomy: Update
2013, Saudi Journal of OphthalmologyCitation Excerpt :However, Morales et al.47 indicated that the effects of ICG are not strongly dose dependent, at least at the physiological concentrations examined. ICG has been found to be associated with the risk of damage to the photoreceptors and RPE cells,48,49 atrophy of the retinal pigment epithelium (RPE),50 loss of epiretinal cellular integrity,51 and cellular toxicity,52–55 among other harmful effects. In conclusion, although much evidence suggests that ICG may exert toxic effects on the retina, the staining agent in low doses should be safe for chromovitrectomy.
Comparison of the In vitro Safety of Intraocular Dyes Using Two Retinal Cell Lines: A Focus on Brilliant Blue G and Indocyanine Green
2009, American Journal of OphthalmologyCitation Excerpt :However, there is also contrary evidence in the literature.31–49 Experimental studies, both ex vivo and in vivo, have shown ICG toxicity to RPE and ganglion/Muller cells.33–40 Histopathological studies have suggested an indistinct cleavage plane between ILM and inner retinal elements.42–43
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Supported in part by Ronald G. Michels Foundation, Beem Fisher Foundation, and Research to Prevent Blindness, Inc.