Original articleTopical Dorzolamide for the Treatment of Cystoid Macular Edema in Patients With Retinitis Pigmentosa
Section snippets
Methods
This study was approved by the internal local institutional review board at the University of Illinois. An informed consent was obtained from all participating subjects, and the study was conducted in accord with The American Health Insurance Portability and Accountability Act (HIPAA) regulations.
All patients seen by the authors within an age range with various genetic subtypes of RP or Usher syndrome type 2 and associated CME were considered for participation in this prospective study. The
Results
Clinically, all fifteen patients showed foveal cysts in at least one eye, with 12 patients showing them in both eyes. The presence of cysts had been documented for a period of at least one to 27 years by one of the authors (G.A.F.) in 12 patients. In three others (patients 1, 3, and 13), cysts were seen on their first visit to the clinic, and soon after, they were enrolled in the study.
Visual acuity improved by seven letters or more from the baseline value in at least one eye in three (20%) of
Discussion
Although the exact mechanism of CME in RP is not known, it has been theorized that, partly, it may be due to an abnormality in retinal pigment epithelial cell polarity, whereby the retinal pigment epithelium cells are unable to effectively pump out ions and, hence, fluid from the outer retina.8 It is postulated that carbonic anhydrase inhibitors may be exerting their therapeutic effect by restoring the polarity and, hence, the function of the retinal pigment epithelium cells.8
On this basis, the
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This study was supported by grants from the Foundation Fighting Blindness, Owings Mill, Maryland, and the Grant Healthcare Foundation, Chicago, Illinois, and by an unrestricted departmental grant from Research to Prevent Blindness, Inc, New York, New York.