Original articleThe OPA1 Gene Polymorphism is Associated With Normal Tension and High Tension Glaucoma
Section snippets
Subjects
Japanese patients with POAG were recruited from ophthalmology practices in the University of Yamanashi Hospital, Enzan City Hospital, Uenohara Town Hospital, and Oizumi Clinic in Yamanashi or Nagano prefectures, Japan. Diagnosis of POAG required open angles on gonioscopic examination, typical glaucomatous cupping of the optic disk with compatible visual field defects by automated static perimetry (Humphrey Visual Field Analyzer 30-2, Humphrey Instruments, San Leandro, California, USA).
Results
One hundred and ninety-four Japanese patients with NTG, 191 patients with HTG, and 185 control subjects were enrolled in this study. The mean age at the time of blood sampling was 63.6 ± 13.3 years standard deviation (SD) in patients with NTG, 62.3 ± 15.1 years in patients with HTG, and 65.3 ± 11.5 years in the control subjects. The mean age at the time of diagnosis was 57.5 ± 13.3 and 54.1 ± 15.6 years in patients with NTG and HTG, respectively. The mean and standard deviation of maximum known
Discussion
Mitochondria are important participants in apoptosis, releasing cytochrome C into the cytoplasm and undergoing extensive mitochondrial fragmentation. The OPA1 gene encodes for a dynamin-related GTPase, a mitochondrial protein implicated in the formation and maintenance of the mitochondrial network and morphology. It was suggested that an initial mitochondrial leak of OPA1 might lead to cristae structural alterations and exposure of previously sequestered protein pools, permitting continued
Fumihiko Mabuchi, MD, PhD, is an instructor of the Department of Ophthalmology at the University of Yamanashi in Yamanashi, Japan. He received his MD and PhD from Yamanashi Medical University in 1993 and 2001, respectively, and then undertook experimental research as an international fellow at Hamilton Glaucoma Center, University of California, San Diego from 2001 to 2003. Dr Mabuchi clinical expertise is diagnosis and management of glaucoma, and current research interests include genetics of
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Fumihiko Mabuchi, MD, PhD, is an instructor of the Department of Ophthalmology at the University of Yamanashi in Yamanashi, Japan. He received his MD and PhD from Yamanashi Medical University in 1993 and 2001, respectively, and then undertook experimental research as an international fellow at Hamilton Glaucoma Center, University of California, San Diego from 2001 to 2003. Dr Mabuchi clinical expertise is diagnosis and management of glaucoma, and current research interests include genetics of primary open-angle glaucoma.
Hiroyuki Iijima, MD, PhD, is a Professor and Chairman of Ophthalmology at the University of Yamanashi since 1999. He earned his medical degree from Tokyo University in 1978 and completed a fellowship in Ophthalmology at Tokyo University. Dr Iijima joined the faculty at Yamanashi, Medical College, the predecessor of the present University of Yamanashi, in 1982. Dr Iijima’s research interests include clinical perimetry, fundus imaging, laser treatment, and genetics in the field of medical retina.