Original articleIndocyanine Green Angiography: Guided Photodynamic Therapy for Polypoidal Choroidal Vasculopathy
Section snippets
Patients and Clinical Evaluation
A retrospective study of 47 eyes from 44 patients with PCV who were treated with PDT at Kyoto University Hospital between August 2004 and October 2005 was carried out. The analysis included the data for the 45 eyes that had at least 12 months of follow-up. All patients were assessed carefully; examinations included FA and ICGA using a scanning laser ophthalmoscope, HRA2 (Heidelberg Engineering, Dossenheim, Germany), and cross-sectional images obtained with optical coherence tomography (OCT;
Results
A retrospective analysis was carried out of 47 eyes from 44 PCV patients. Two patients were excluded from the study because of incomplete examinations. The average age of the 45 patients was 73 years; there were 12 women and 33 men. All patients were of Japanese origin. The average number of PDT treatments was 1.22 ± 0.47 (± standard deviation [SD]). Details are shown in the Table.
Discussion
In this study, we showed the efficacy of ICGA-guided PDT for treating symptomatic, subfoveal PCV. Similar to the previous reports,9, 10, 23, 24, 25 significant improvement in VA was observed at both three and 12 months after PDT, and more than 80% of patients had improved or stabilized VA.
The GLD was determined based on the ICGA findings and included all of the vascular abnormalities, including polypoidal lesions and branching vascular networks. Unlike the standard protocol used in the VIP
Atsushi Otani, MD, PhD, is an Assistant Professor of Ophthalmology at Kyoto University, Kyoto, Japan. He received MD and PhD at Kyoto University Graduate School of Medicine. In 2000 to 2003, Dr Otani was a research fellow at Dr Martin Friedlander’s lab of The Scripps Research Institute; La Jolla, California. His interests focus is on retinal diseases including macular diseases and retinal degeneration.
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Atsushi Otani, MD, PhD, is an Assistant Professor of Ophthalmology at Kyoto University, Kyoto, Japan. He received MD and PhD at Kyoto University Graduate School of Medicine. In 2000 to 2003, Dr Otani was a research fellow at Dr Martin Friedlander’s lab of The Scripps Research Institute; La Jolla, California. His interests focus is on retinal diseases including macular diseases and retinal degeneration.