Original articleLong-term outcomes in asians after acute primary angle closure☆
Section snippets
Materials and methods
Written informed consent was obtained from study subjects, and the study protocol had the approval of the Ethics Committees of the Singapore National Eye Centre, the National University Hospital, Singapore, and the Wilmer Institute, Johns Hopkins University.
The first part of the study was a systematic review of the charts of consecutive patients who were seen with APAC at the National University Hospital, Singapore, from 1990 to 1995 and at the Singapore National Eye Centre in 1996.
The
Results
There were a total of 170 subjects who were seen with APAC at the National University Hospital, Singapore, from 1990 to 1995 and at the Singapore National Eye Centre in 1996. Thirty-two subjects were deceased before the time of the examination. Of the remaining 138 eligible subjects, 22 (15.9%) could not be contacted, and 26 subjects (18.8%) refused or were medically unwell to come for an examination, leaving a total of 90 subjects who participated in the study (65.2% response rate). The mean
Discussion
This is the first study to investigate the long-term visual outcome several years after an episode of APAC in Asians. With a mean interval of 6 years from presentation to the time of examination, one fifth of APAC subjects were found to be blind in the attack eye, with glaucoma being the cause of blindness in 50% of them. Almost half of all subjects were found to have glaucomatous optic neuropathy, and a third of those with glaucoma had severely cupped optic discs (C/D ratio > 0.9).
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Manuscript no. 230350.
Supported by a grant from Johns Hopkins Singapore PTE Ltd. Dr Aung is partly supported by the National Medical Research Council of Singapore.