Original articlePatterns of regional and distant metastasis in patients with eyelid and periocular squamous cell carcinoma☆
Section snippets
Materials and methods
Appropriate institutional review board approval was obtained for this retrospective review. The patients included in this study were identified through a search of the Tumor Registry database at The University of Texas M. D. Anderson Cancer Center. One hundred eleven patients with eyelid and periocular skin SCC treated between 1952 and 2002 and for whom at least 6 months of follow-up data were available were identified. The clinical records were reviewed retrospectively. Information analyzed
Results
Patient characteristics and patterns of recurrence are summarized in Table 1. The age of diagnosis ranged from 31 to 91 years (median, 64). Eighty-nine men and 22 women were affected. The follow-up time ranged from 6 to 484 months (median, 76.6) after the exclusion of 2 patients who had a follow-up time of <6 months but were included in this study because they had regional nodal metastasis (the main outcome measure for this study) when the SCC was initially diagnosed. One hundred seven patients
Discussion
The incidence of regional lymph node metastasis secondary to eyelid and periocular SCC in the present study (24.3%) is relatively high compared with the incidence previously reported.1, 3, 5, 15 The previously reported incidences of regional lymph node metastasis associated with SCC of the eyelid and periocular skin have varied widely, from as low as 10% to as high as 21.4% in different retrospective series.1, 8 The current study represents one of the largest series of eyelid and periocular
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Recommendations for risk stratification of periocular squamous cell carcinoma
2023, Survey of OphthalmologySquamous cell carcinoma of the conjunctiva. Case report
2022, International Journal of Surgery Case ReportsCitation Excerpt :In these cases, the risk of invasion in to the orbit, perineural invasion (8% to 14%), and lymphatic or hematogenous metastasis is higher [28]. The incidence of metastasis in the regional lymph node is up to 24% with most regional metastasis occurring in the parotid and submandibular nodes [18] and distant metastasis is reported in 6.2% of cases [29]. The Anderson Cancer Center showed that patients with invasive SCC (T3 or greater AJCC) or tumor diameter larger than 18 mm had nodal metastases, and the 3-year disease-free survival rate was 79% [30].
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2020, Disease-a-MonthSquamous cell carcinoma of the eyelid
2024, Japanese Journal of Clinical OncologySentinel node mapping in conjunctival and eyelid malignancies: a mini-review
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